摘要
文章建立了气相色谱质谱联用技术(GC-MS)测定塑料药用滴眼剂瓶中多环芳烃(PAHs)及其迁移的方法,采用HP-5MS毛细管色谱柱(30 m×0.25 mm×0.25μm)对16种PAHs进行分离,离子监测模式(SIM)下进行检测。结果表明:16种PAHs在相应的浓度范围内线性关系良好(R^(2)≥0.997),提取实验回收率在80.28%~117.09%范围内,相对标准偏差(RSD)在1.44%~5.81%之间;迁移实验回收率在82.63%~116.73%,相对标准偏差(RSD)在1.38%~3.80%之间。提取实验检出限为0.005~0.050μg/g,迁移实验检出限为0.001~0.010 mg/L。此方法操作简单、准确、灵敏,适用于塑料药用滴眼剂瓶中PAHs及其迁移量的测定。
A method for the determination of polycyclic aromatic hydrocarbons(PAHs)and their migration in plastic eye drops bottles by gas chromatography-mass spectrometry(GC-MS)was established.16 kinds of PAHs were separated by HP-5MS capillary column(30 m×0.25 mm×0.25μm)and detected under ion monitoring mode(SIM).The results show that 16 kinds of PAHs has a good linear relationship in the corresponding concentration range(R^(2)≥0.997).The recovery rate of extraction experiment is in the range of 80.28%~117.09%,and the relative standard deviation(RSD)is between 1.44%~5.81%.The recovery rate of migration experiment is 82.63%~116.73%,and the relative standard deviation(RSD)is 1.38%~3.80%.The detection limit of extraction experiment is 0.005~0.050μg/g,and the detection limit of migration experiment is 0.001~0.010 mg/L.This method is simple,accurate and sensitive,and is suitable for the determination of PAHs and their migration in plastic pharmaceutical eye drops bottles.
作者
饶艳春
汪元亮
章瑛
左军凤
常亮
RAO Yan-chun;WANG Yuan-liang;ZHANG Ying;ZUO Jun-feng;CHANG Liang(Jiangxi Institute for Drug Control,NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine,Jiangxi Province Engineering Research Center of Drug and Medical Device Quality,Nanchang 330029,China)
出处
《塑料科技》
CAS
北大核心
2023年第9期88-92,共5页
Plastics Science and Technology
基金
江西省药品监督管理局科研项目(2021KY01)。
关键词
多环芳烃
塑料药用滴眼剂瓶
迁移
气相色谱-质谱法
Polycyclic aromatic hydrocarbons
Plastic medicinal eye drops bottle
Migration
GC-MS
