摘要
帕金森病(PD)是多发于中老年人的神经退行性疾病,由于病因未明,目前仍缺乏有效的治疗方法。近年来越来越多的证据表明胃肠道菌群在PD的发生和发展中发挥着重要作用。本文基于PD起源于肠道的Braak假说,结合中医肾虚血瘀的理论,探讨了在胃肠道菌群失调、肾虚血瘀等状态下,氨代谢紊乱对中枢神经系统造成慢性损伤的过程,认为氨很可能是导致PD的关键因素。
Parkinson s disease(PD)is a neurodegenerative disease that occurs mostly in middle-aged and elderly people,and there is still a lack of effective treatments due to the unknown cause.In recent years,more and more evidence has shown that gastrointestinal microbiota plays an important role in the occurrence and development of PD.In this paper,based on the Braak hypothesis that PD originates from the intestine and combined with the theory of kidney deficiency and blood stasis in traditional Chinese medicine,we discussed the process of chronic damage to the central nervous system caused by disorders of ammonia metabolism in the state of imbalance of gastrointestinal microbiota and kidney deficiency and blood stasis,and concluded that ammonia was likely to be a key factor leading to PD.
作者
杨文学
李敏
李明伟
杨明会
YANG Wenxue;LI Min;LI Mingwei;YANG Minghui(Department of Traditional Chinese Medicine,Chinese PLA General Hospital,Beijing 100853,China)
出处
《空军军医大学学报》
CAS
2023年第10期1002-1005,1010,共5页
Journal of Air Force Medical University
基金
国家自然科学基金面上项目(82130117)。
关键词
帕金森病
Braak假说
氨
肾虚血瘀
肠道菌群
Parkinson's disease
Braak hypothesis
ammonia
kidney deficiency and blood stasis
intestinal microbiota
