摘要
手性是自然界的基本属性之一,在生物体功能实现中起着至关重要的作用.虽然手性对映异构体具有相似的结构和理化性质,但其手性信号和功能却完全不同,因此,研究手性在生物医学光子学领域的作用具有重要的科学意义和实用价值.此前,大多数关于手性的研究都集中在有机分子手性材料中,蛋白质、糖和合成手性分子等分子水平上的手性得到了深入研究.随着纳米技术的发展,人们对手性的研究从分子尺度拓展到了纳米尺度,然而手性与手性信号在纳米尺度下的形成机制和表现出的各种现象仍不明确.近年来,研究者利用自组装法、化学合成法等,通过改变纳米粒子的组成、结构、形貌等,合成了多种手性纳米粒子.这些手性纳米粒子在光学、电子学以及生物医学光子学等领域展现出独特的性质和应用价值.金纳米粒子以其光学特性稳定、等离子共振峰位易调谐、生物相容性好等特性被广泛应用于生物医学光子学领域的研究中.将手性引入金纳米粒子,使其具有与生命体类似的手性性质,对于深入理解生命活动中的手性现象,并提升其应用性能具有非常重要的意义.因此,手性金纳米粒子的合成及其在生物医学光子学领域的应用成为近年来的研究热点.本文介绍了近年来手性金纳米粒子的合成及其在生物医学光子学领域的应用进展.首先,详细介绍了手性金纳米粒子的手性起源,包括结构手性、配体诱导手性以及通过自组装的方式诱导产生手性;随后,介绍了其在生物传感、对映体识别和光疗等方面的应用进展;最后,分析了将手性金纳米粒子应用于生物医学光子学领域所面临的挑战,预计手性金纳米粒子将在生物医学光子学领域展现出越来越大的影响力.
Chirality,the property of a molecule or object being non-superimposable on its mirror image,has fascinated scientists for centuries due to the crucial role it plays in the implementation of biological functions.Enantiomers,which are molecules that are mirror images of each other and possess different chiral signals and functions,have been extensively studied for their practical applications in various fields,particularly biomedicine.The study of chirality has largely focused on chiral organic materials,but recent advances in nanotechnology have allowed the extension of chirality studies from the molecular level to the nanoscale.Nanoparticles are particles with a size range of one to 100 nanometers and have unique physical properties that differ from those of their bulk counterparts.Chiral nanoparticles have been successfully synthesized by altering their composition,structure,and morphology through self-assembly and chemical synthesis.These nanoparticles exhibit unique physical properties and have various applications in optoelectronics,biomedicine,and other fields.Gold nanoparticles,in particular,have garnered widespread interest due to their stable optical properties,easy-totune plasmon resonance peak,and excellent biocompatibility.By introducing chirality into gold nanoparticles,we obtain chiral properties similar to those observed in living organisms,providing essential insights into understanding chirality phenomena in life activities while improving their application performance.One recent research hotspot is the synthesis of chiral gold nanoparticles and their application in biomedical photonics.Biomedical photonics involves the use of light in medicine and biology for diagnosis and therapy.Chiral nanoparticles have shown great potential in sensing,enantioselective recognition,and phototherapy.Enantioselective recognition is a recent discovery in the field and is particularly useful in drug discovery and personalized medicine.By using chiral gold nanoparticles,it is possible to selectively detect and isolate enantiomers of a given molecule,allowing for the development of personalized medicine tailored to a patient’s specific needs.However,applying chiral gold nanoparticles in the field of biomedical photonics poses some challenges.One such challenge is biocompatibility and toxicity.Since nanoparticles can enter cells and tissues,it is important to ensure that they do not cause harm.Additionally,the synthesis and characterization of chiral nanoparticles at the nanoscale remain obscure,posing a new challenge and an opportunity for researchers.Despite these challenges,the advancements in the synthesis of chiral gold nanoparticles and their application in biomedical photonics hold great promise for the development of novel therapies that could revolutionize medicine.The continued progress in chirality research could enable us to leverage chirality for developing treatments for various diseases,including personalized medicine.Therefore,it is important to continue exploring the properties of chiral gold nanoparticles,with high expectations of their application and influence in the field of biomedicine photonics to continue to grow.In conclusion,the study of chirality at the nanoscale and its exceptional applications in various biomedical areas,using chiral gold nanoparticles,exhibits tremendous potential to open new horizons and opportunities.The advancements in this area pave the way for novel therapies that could revolutionize medicine,leading to better patient outcomes and personalized treatments.The continued progress in chirality research holds great promise for the future of medicine,and we look forward to seeing the developments that continue to unfold in this exciting field.
作者
岳安玉
王倩
翁玉龙
贺宇路
郭立俊
Anyu Yue;Qian Wang;Yulong Weng;Yulu He;Lijun Guo(School of Physics and Electronics,Henan University,Kaifeng 475004,China)
出处
《科学通报》
EI
CAS
CSCD
北大核心
2023年第27期3582-3593,共12页
Chinese Science Bulletin
基金
国家自然科学基金(61905066,22105063,12004101,11874438)资助。
关键词
手性金纳米粒子
手性起源
手性生物传感
对映体识别
手性光疗
chiral gold nanoparticles
chiral origins
chiral biosensing
enantioselective recognition
chiral phototherapy
