摘要
目的探究循环肿瘤细胞(CTCs)与甲状腺癌侵犯喉返神经及结构性复发之间的相关性。方法选取手术治疗的分化型甲状腺癌患者72例,根据其术后复发情况分为结构性复发组21例,未复发组51例,根据喉镜检查结果分为侵犯喉返神经组19例,未侵犯喉返神经组53例。所有患者术前均进行CTCs检测,对比各组患者的CTCs阳性情况,分析循环肿瘤细胞与甲状腺癌预后情况之间的关系。结果复发组CTCs阳性率71.42%,未复发组CTCs阳性率45.09%,2组对比差异具有统计学意义(P<0.05)。侵犯喉返神经组CTCs阳性率84.21%,未侵犯喉返神经组CTCs阳性率41.50%,2组对比差异具有统计学意义(P<0.05)。肿瘤数目、肿瘤大小与CTCs阳性情况无明显相关(P>0.05),肿瘤分期与CTCs阳性情况存在联系(P<0.05)。将肿瘤分期、甲状腺侵犯喉返神经、术后复发作为自变量对影响CTCs做Logistic因素分析,结果显示肿瘤分期、甲状腺侵犯喉返神经、术后复发均为影响CTCs的独立危险因素(P<0.001)。CTCs对甲状腺侵犯喉返神经诊断的灵敏度为69.5%、特异度为82.4%,对甲状腺癌术后复发诊断的灵敏度为62.1%、特异度为91.2%。结论CTCs阳性与甲状腺癌术后结构性复发相关,同时对甲状腺癌侵犯喉返神经具有一定的评估价值。
Objective To explore the correlation of circulating tumour cells(CTCs)with invasion of recurrent laryngeal nerve and structural recurrence in thyroid cancer.Methods 72 patients with differentiated thyroid cancer underwent surgical treatment were selected,and divided into recurrence group(n=21)and non-recurrence group(n=51)according to the presence or absence of postoperative recurrence,and re-classified into recurrent laryngeal nerve invasion group(n=19)and non-recurrent laryngeal nerve invasion group(n=53)according to the results of laryngoscopy.All patients underwent preoperative CTCs testing,then the correlation of circulating tumor cells and prognostic status of thyroid cancer was discussed.Results The CTCs positive rate was 71.42%in recurrence group,which was 5.09%in non-recurrence group,with statistical difference(P<0.05).The CTCs positive rate was 84.21%in recurrent laryngeal nerve invasion group,which was 41.50%in non-recurrent laryngeal nerve invasion group,with statistical difference(P<0.05).The tumor number and tumor size yielded no correlation with CTCs positive rate(P>0.05),while tumor stage was obviously correlated with CTCs positive rate(P<0.05).Taking tumor stage,recurrent laryngeal nerve invasion and postoperative recurrence as independent variables,Logistic regression analysis showed that tumor stage,invasion of recurrent laryngeal nerve and postoperative recurrence were independent risk factors for CTCS(P<0.001).The sensitivity and specificity of CTCs in the diagnosis of thyroid recurrent laryngeal nerve invasion were 69.5%and 82.4%,and the sensitivity and specificity of CTCs in the diagnosis of postoperative thyroid cancer recurrence were 62.1%and 91.2%.Conclusion Positive CTCs is associated with postoperative structural recurrence of thyroid cancer,and has certain evaluation value for thyroid cancer invading the recurrent laryngeal nerve.
作者
张瑞瑞
陈瑞君
宋白利
ZHANG Ruirui;CHEN Ruijun;SONG Baili(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,471000)
出处
《实用癌症杂志》
2023年第10期1608-1611,共4页
The Practical Journal of Cancer
关键词
甲状腺癌
喉返神经
循环肿瘤细胞
复发
Thyroid cancer
Recurrent laryngeal nerve
Circulating tumor cells
Recurrence
