摘要
目的:观察丹蛭降糖胶囊联合阿托伐他汀钙对早期糖尿病心肌病患者的临床疗效及炎症指标的影响。方法:将60例早期糖尿病心肌病患者随机分为对照组和治疗组,每组各30例。两组均采取基础降糖治疗,对照组口服阿托伐他汀钙片;治疗组在对照组的基础上加用丹蛭降糖胶囊治疗。两组均治疗12周。观察两组患者治疗前后血糖血脂、心功能和炎症指标及疗效情况。结果:与治疗前比较,两组治疗后空腹血糖(Glucose,GLU)、餐后2 h血糖(2-hour Postprandial Blood Glucose,2 h PG)、糖化血红蛋白(HbA1c)、总胆固醇(Total Cholesterol,TC)、三酰甘油(Triglyceride,TG)、低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol,LDL-C)、超敏C反应蛋白(High Sensitive C-reactive Protein,hs-CRP)、白细胞介素(Interleukin,IL)-6、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)均降低(P<0.05或P<0.01),治疗组高密度脂蛋白胆固醇(High Density Lipoprotein Cholesterol,HDL-C)升高(P<0.05),两组左心室射血分数(Left Ventricular Ejection Fraction,LVEF)、二尖瓣舒张早期最大速度/心房收缩期最大速度(Mitral valve early diastolic maximum velocity/Maximum atrial systole velocity,E/A)值均提高(P<0.05);与对照组比较,治疗组治疗后GLU、2 h PG、HbA1c、TC、TG、LDL-C、hs-CRP、IL-6、TNF-α均明显降低,HDL-C和LVEF、E/A值升高显著(P<0.05或P<0.01)。治疗组中医证候疗效优于对照组(P<0.05)。结论:丹蛭降糖胶囊联合阿托伐他汀钙治疗早期糖尿病心肌病能提高中医证候疗效,辅助降糖调脂、改善心室舒张功能及降低炎症反应。
Objective:To observe the effect of the Danzhi Jiangtang capsules(丹蛭降糖胶囊)with atorvastatin calcium on early diabetic cardiomyopathy and inflammatory indexes of patients.Methods:Sixty patients with early diabetic cardiomyopathy were randomly divided into the control group and treatment group,with 30 cases in each group.Both groups received basic hypoglycemic treatment,and the control group took atorvastatin calcium tablet orally.The treatment group was treated with the Danzhi Jiangtang capsules on the basis of treatment in the control group.Both groups were treated for 12 weeks.Blood glucose and lipid,cardiac function,inflammatory indexes and curative effects were observed in 2 groups before and after treatment.Results:Compared with before treatment,GLU,2 h PG,HbA1 c,TC,TG,LDL-C,hs-CRP,IL-6 and TNF-αwere decreased in 2 groups after treatment(P<0.05 or P<0.01),while HDL-C was increased in the treatment group(P<0.05).LVEF and E/A values were increased in both groups(P<0.05).Compared with the control group,GLU,2 h PG,HbA1c,TC,TG,LDL-C,hs-CRP,IL-6 and TNF-αin the treatment group were significantly decreased after treatment,while HDL-C,LVEF and E/A values were significantly increased in the treatment group(P<0.05 or P<0.01).The curative effect of TCM syndrome in the treatment group was better than that in the control group(P<0.05).Conclusion:The Danzhi Jiangtang capsules with atorvastatin calcium in the treatment of early diabetic cardiomyopathy can improve the efficacy of TCM syndrome,assist to reduce blood glucose,regulate blood lipid level,improve ventricular diastolic function,and reduce inflammatory response.
出处
《中医临床研究》
2023年第26期113-117,共5页
Clinical Journal Of Chinese Medicine
基金
国家自然科学基金项目(81774286,81603574,81573944,82174153)
国家中医临床研究基地业务建设第二批科研专项(JDZX2015123)
国家重点研发计划“战略性国际科技创新合作”重点专项(2020YFE0201800)
国家重点研发计划“中医药现代化研究”重点专项(2018YFC1704202,2019YFC1709203-4)
安徽省高校自然科学研究重点项目(KJ2020A0383)
安徽省自然科学基金(1708085QH213)
安徽省高校协同创新项目(GXXT-2020-025)
第五批省“特支计划”人才项目(dwps“tzjh”rcxm20190028)
安徽省中医药领军人才及培养对象项目(2019ahszyyljrcxm20190027)
方朝晖安徽省名中医工作室(2019-8-515)
安徽中医药大学2020年自然科学研究重点项目(2020yfyzc24)
2021年安徽中医药大学临床科研项目(2021yfylc07)
2022年新安医学教育部重点实验室开放课题重点项目(2022xayx05)
2021年安徽中医药大学纵向探索性科研项目(2021zxts57)
2020年安徽省教学质量工程项目(2020xsjxms135)
安徽中医药大学教学研究重点项目(2021xjjy_zd036)。
关键词
丹蛭降糖胶囊
早期糖尿病心肌病
临床疗效
炎症
The Danzhi Jiangtang capsules
Early diabetic cardiomyopathy
Clinical efficacy
Inflammation
