摘要
目的:探讨基于真实世界中医辨证治疗方案用于高血压与焦虑症共病的临床疗效。方法:选取2018年1月至2020年8月河南省中医药研究院附属医院和河南省人民医院收治的高血压与焦虑症共病的180例患者作为研究对象。采用前瞻性队列研究,根据是否应用中药分为观察组101例和对照组79例,采用倾向评分法共匹配58对病例,进行同期队列对照。2组均给予苯磺酸氨氯地平联合草酸艾司西酞普兰治疗,观察组增加中药辨证治疗,观察指标为血压值、汉密尔顿焦虑量表(HAMA)和中医证候积分。治疗周期为8周。结果:观察组疗效优于对照组(P<0.05)。治疗后,2组收缩压值差异无统计学意义(P>0.05),收缩压差值、舒张压值及差值、HAMA评分值及差值、中医证候积分值及差值、中医证候积分疗效差异均有统计学意义(均P<0.05);治疗6、8周后2组收缩压、舒张压、HAMA评分值及中医证候积分值均下降,8周较6周差值更大,差异有统计学意义(P<0.05)。结论:中医药治疗高血压与焦虑症共病的疗效显著,在辅助降压的同时,具有缓解焦虑,改善中医临床症状的作用,且随治疗周期延长,疗效更加明显。
Objective:To explore the therapeutic effect of the TCM syndrome differentiation and treatment program on hypertension complicated with anxiety based on real-world data.Methods:A prospective cohort study was conducted involving 180 patients with both hypertension and anxiety treated in the Henan Integrative Medicine Hospital and Henan Provincial People′s Hospital.The patients were assigned into an observation group(n=101)and a control group(n=79).A total of 58 pairs of patients were matched by the propensity scoring method for concurrent cohort comparison.Both groups were treated with amlodipine besylate combined with escitalopram oxalate,and the observation group was additionally treated with Chinese medicine based on syndrome differentiation.The treatment lasted for 8 weeks and the blood pressure,Hamilton Anxiety Scale(HAMA)score,and TCM syndrome score were measured for the two groups.Results:The treatment effect of the observation group was better than that of the control group(P<0.05).After treatment,there was no significant difference in the systolic blood pressure between the two groups(P>0.05),while the difference in systolic blood pressure,diastolic blood pressure and its difference,HAMA score and its difference,TCM syndrome score and its difference,and clinical efficacy in terms of TCM syndrome score had significant differences between the two groups(all P<0.05).After 6 and 8 weeks of treatment,the systolic blood pressure,diastolic blood pressure,HAMA score,and TCM syndrome score decreased in both groups,and the differences were greater at the 8th week than at the 6th week(P<0.05).Conclusion:The TCM syndrome differentiation and treatment program demonstrates a significant therapeutic effect on hypertension complicated with anxiety.While lowering blood pressure,this therapy can relieve anxiety and TCM symptoms in a time-dependent manner.
作者
林萍
崔伟锋
雷斯媛
郭泉滢
庆慧
LIN Ping;CUI Weifeng;LEI Siyuan;GUO Quanying;QING Hui(Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Academy of Chinese Medicine,Zhengzhou 450004,China)
出处
《世界中医药》
CAS
2023年第17期2488-2491,2497,共5页
World Chinese Medicine
基金
国家自然科学基金项目(81273877)
河南省中医药科学研究专项重点课题(2018ZY01019)。
关键词
中医药
高血压
焦虑症
真实世界研究
前瞻性队列研究
倾向评分法
中医辨证治疗
疗效研究
Chinese medicine
Hypertension
Anxiety
Real-world study
Prospective cohort study
Propensity scoring method
TCM syndrome differentiation and treatment
Efficacy evaluation
