摘要
癌相关成纤维细胞是肿瘤微环境中数目最为丰富的基质细胞。越来越多的研究发现癌相关成纤维细胞对肿瘤的发生发展发挥着巨大作用。癌相关成纤维细胞不仅能够重塑细胞外基质,调节肿瘤代谢,参与免疫调节,还能促进肿瘤的生长、血管生成、迁移和侵袭等。因此,破坏癌相关成纤维细胞与周围环境的交互可能提供新的治疗思路。本文将对癌相关成纤维细胞在口腔鳞状细胞癌中的研究进展进行综述。
Cancer-associated fibroblasts are the most abundant stromal cells in the tumor microenvironment.An increasing number of studies have found that cancer-associated fibroblasts play a remarkable role in the development of tumors.Cancer-associated fibroblasts remodel the extracellular matrix,regulate tumor metabolism,and participate in immune regulation,and promote tumor growth,angiogenesis,migration,and invasion.Therefore,disrupting the interaction between cancer-associated fibroblasts and the surrounding environment may provide us with new therapeutic ideas.In this paper,we will review the research progress on cancer-associated fibroblasts in oral squamous carcinoma.
作者
吴佳敏
夏斌
杨禾丰
许彪
Wu Jiamin;Xia Bin;Yang Hefeng;Xu Biao(Dept.of Oral and Maxillofacial Surgery,Affiliated Stomatological Hospital of Kunming Medical University,Kunming 650500,China)
出处
《国际口腔医学杂志》
CAS
CSCD
2023年第6期711-717,共7页
International Journal of Stomatology
基金
云南省口腔医学重点实验室项目(202005AG070041)
云南省卫生健康委员会内设机构项目(2018NS0210)。
关键词
癌相关成纤维细胞
口腔鳞状细胞癌
肿瘤微环境
cancer-associated fibroblast
oral squamous cell carcinoma
tumor microenvironment
