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血管衰老分子靶点及干预的研究进展

Research progress on molecular targets and results of targeted interventions of vascular aging
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摘要 血管衰老是血管壁结构和功能随年龄增长逐渐退化损伤的过程,可增加心血管疾病的风险。本文系统回顾了血管衰老的分子机制,从DNA损伤应答、细胞周期阻滞、衰老相关分泌表型、线粒体功能障碍以及代谢紊乱等方面,介绍了血管衰老分子干预靶点的研究进展,展望了延缓血管衰老的潜在策略,旨在为血管衰老的防控提供帮助。
作者 张唯薇 曹丰 Weiwei Zhang;Feng Cao(Department of Cardiology,Second Medical Center,Chinese People′s Liberation Army General Hospital,National Clinical Research Center for Geriatric Diseases,Beijing 100853,China)
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2023年第10期1104-1108,共5页 Chinese Journal of Cardiology
基金 国家重点研发计划(2022YFC3602400) 国家自然科学基金(92249301)。
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