摘要
东方田鼠是已知的唯一一种天然抗日本血吸虫病的哺乳动物。来源于血吸虫病疫区和非疫区以及实验室培育的东方田鼠对日本血吸虫有着相同的抗性。野生东方田鼠经过30多年的实验室培育,已经实现了实验动物化。同时,研究人员对东方田鼠的生长发育、生殖生理、血清生化、血液学指标、组织解剖等生物学性状进行了较详细的研究,并且进一步深入探讨了东方田鼠的抗血吸虫病特性及机制。上海实验动物研究中心培育的洞庭湖东方田鼠封闭种群(S:DTMF)在2021年经中国实验动物学会实验动物资源与评价工作委员会认定为中国实验动物资源。本综述着重总结近10年,特别是国家科技支撑计划项目实施中在东方田鼠生物学特性、标准化、基因组以及抗血吸虫病机制等方面的研究进展。
Microtus fortis(reed vole)is the only mammal known to have natural resistance to Schistosomiasis japonica.Originating from schistosomiasis endemic and non-endemic areas,as well as laboratory bred voles have the same resistance to Schistosomajaponicum.After more than 30 years of laboratory cultivation of wild reed vole,a series of progress have been made in laboratory animalization.A detailed study was conducted on biological traits including growth and development,reproductive physiology,serum biochemistry,hematological indicators and tissue anatomy.At the same time,the anti-schistosomiasis characteristics and anti-schistosomiasis mechanisms of Microtusfortiswere studied.The closed Dongtinghu population of Microtusfortis(S:DTMF)cultivated by Shanghai Laboratory Animal Research Center was recognized as a Chinese laboratory animal resource by the Experimental Animal Resources and Evaluation Working Committee of the Chinese Association for Laboratory Animal Sciences in 2021.This review focuses on summarizing the research progress in the biological characteristics,standardization research,genome and anti-schistosomiasis mechanism of reed vole in the past decade,especially in the implementation of the key project in the National Science and Technology Pillar Program.
作者
谢建芸
XIE Jianyun(Shanghai Laboratory Animal Research Center,Shanghai 201203,China)
出处
《实验动物与比较医学》
CAS
2023年第5期482-491,共10页
Laboratory Animal and Comparative Medicine
基金
国家重点研发计划项目“东方田鼠抗血吸虫病和大脑中动脉缺血模型的创建及关键技术研究”(2021YFF0702403)
国家科技支撑计划“东方田鼠种质资源库的建立及其抗血吸虫病机制的研究”(2015BAI09B04)。
关键词
东方田鼠
实验动物化
抗血吸虫病
Microtusfortis
Laboratory animalization
Anti-schistosomiasis
