摘要
目的探讨左乙拉西坦联合丙戊酸钠对缺血性卒中(IS)后癫痫患者脑电图功率谱、神经功能、不良反应、癫痫发作及病情控制情况的影响。方法选择2021年10月至2022年10月江西省人民医院收治的50例IS后癫痫患者,按随机数字表法分为对照组与试验组,每组各25例。对照组采用丙戊酸钠治疗,试验组采用左乙拉西坦联合丙戊酸钠治疗,两组均治疗8周。比较分析两组脑电图功率谱变化、神经功能恢复情况、癫痫发作情况、病情控制率、不良反应。结果治疗后,试验组的α频段脑电相对功率、β频段脑电相对功率均高于对照组,δ频段脑电相对功率、θ频段脑电相对功率、美国国立卫生研究院卒中量表(NIHSS)评分均低于对照组,癫痫发作次数少于对照组,癫痫发作持续时间短于对照组,差异有统计学意义(P<0.05)。试验组的病情控制率为100.00%,高于对照组的76.00%,差异有统计学意义(P<0.05)。两组患者在用药期间均未发生不良反应。结论左乙拉西坦联合丙戊酸钠能够对IS后癫痫患者脑电图功率谱变化产生正性影响,提高α、β频段脑电相对功率,下调δ、θ频段脑电相对功率,改善癫痫发作与神经功能,积极控制病情,且安全性较高。
Objective To investigate the effect of Levetiracetam combined with Sodium Valproate on electroencephalogram power spectrum,neurological function,adverse reactions,seizures and disease control in patients with epilepsy after is-chemic stroke(IS).Methods A total of 50 patients with epilepsy after IS admitted to Jiangxi Provincial People's Hospital from October 2021 to October 2022 were selected and divided into control group and experimental group according to the random number table method,with 25 cases in each group.The control group was treated with Sodium Valproate,and the experimental group was treated with Levetiracetam combined with Sodium Valproate.Both groups were treated for 8 weeks.The changes of electroencephalogram power spectrum,neurological function recovery,seizures,disease control rate,and ad-verse reactions were compared between the two groups.Results After treatment,theαband electroencephalogram relative power andβband electroencephalogram relative power of the experimental group were higher than those of the control group,theδband electroencephalogram relative power,θband electroencephalogram relative power,National Institutes of Health stroke scale(NIHSS)score were lower than those of the control group,the number of seizures was less than that of the control group,and the duration of seizures was shorter than that of the control group,with statistically significant differences(P<0.05).The disease control rate of the experimental group was 100.00%,which was higher than 76.00%of the control group,and the difference was statistically significant(P<0.05).No adverse reactions occurred in the two groups during the treatment.Conclusion Levetiracetam combined with Sodium Valproate can have a positive effect on the change of elec-troencephalogram power spectrum in patients with epilepsy after IS,increase the relative power ofαandβfrequency band electroencephalogram,and reduce the relative power ofδandθfrequency band electroencephalogram,improve seizures and neurological function,and actively control the disease with high safety.
作者
邹冬琴
康钦
柴文
ZOU Dongqin;KANG Qin;CHAI Wen(Department of Neurology,Jiangxi Provincial People's Hospital,the First Affiliated Hospital of Nanchang Medical College,Jiangxi Province,Nanchang 330006,China)
出处
《中国当代医药》
CAS
2023年第30期83-86,共4页
China Modern Medicine
基金
江西省卫生健康委科技计划项目(202210153)。
关键词
缺血性卒中
癫痫
左乙拉西坦
丙戊酸钠
脑电图功率谱变化
神经功能
Ischemic stroke
Epilepsy
Levetiracetam
Sodium Valproate
Electroencephalogram power spectrum changes
Neurological function
