摘要
免疫球蛋白G4(IgG4)相关性疾病(IgG4-RD)是近年来受关注度较高的一类慢性、系统性疾病。IgG4-RD可累及全身各个组织,主要表现为累及器官的肿胀及占位改变,当病变侵犯至眼部周围时称为IgG4相关性眼病(IgG4-ROD),主要侵犯泪腺、眼眶脂肪、眶下神经、眼外肌和眼睑等。目前,针对IgG4-ROD的主要治疗方式有药物治疗、手术、放射治疗等。随着近年对该病认识的不断提升,治疗有效率不断提高,本文就IgG4-ROD的流行病学特点、临床表现、影像特点、诊断和治疗的最新进展进行综述。
Immunoglobulin G4-related diseases(IgG4-RD)are chronic,systemic diseases that have received much attention in recent years.IgG4-RD can affect almost all tissues of the body,mainly manifested by swelling and space-occupying changes in the involved sites.It is called IgG4-related ophthalmic disease(IgG4-ROD)when the lesions invade the ocular area.The disease mainly invades the lacrimal glands,orbital fat,infraorbital nerve,extraocular muscles,and eyelids.At present,the main treatment modalities for IgG4-ROD include medication,surgery,and radiation therapy,etc.With the enhanced understanding of the disease and the increasing cure rate in recent years,this article reviews the latest progress in the epidemiological characteristics,clinical manifestations,imaging features,diagnosis and treatment of IgG4-ROD.
作者
陈伊琛
俞丹洋
Yi-Chen Chen;Dan-Yang Yu(Department of Ophthalmology,the 920th Hospital of Joint Logistic Support Force,Kunming 650032,Yunnan Province,China;Kunming Medical University,Kunming 650500,Yunnan Province,China)
出处
《国际眼科杂志》
CAS
北大核心
2023年第11期1849-1853,共5页
International Eye Science
