摘要
目的 探究宫颈癌中CA125、CA153、CRP/ALB水平变化及与肿瘤侵袭转移的相关性。方法 选取158例宫颈癌患者作为研究组(n=158),选取同期进行体检的76例健康女性作为对照组(n=76)。对2组研究对象血清中CA125、CA153、CRP/ALB的水平进行比较,分析宫颈癌患者血清中CA125、CA153、CRP/ALB水平与临床分期及病理特征的关系,采用Spearman分析血清中CA125、CA153、CRP/ALB水平与临床分期的相关性,宫颈癌患者血清中CA125、CA153、CRP/ALB单独及联合检测的诊断价值。结果 研究组患者血清中CA125、CA153的水平及CRP/ALB比值均明显高于对照组(P<0.05)。肿瘤直径≥4 cm的患者三项指标水平均明显高于直径<4 cm的患者(P<0.05);临床分期与三项指标呈正相关,分期越高其表达水平越高(P<0.05);腺癌患者的三项指标水平也均明显高于鳞癌患者(P<0.05);存在淋巴结转移患者的三项指标均明显高于无转移的患者(P<0.05)。经Spearman相关性分析可知,临床分期、肿瘤直径与患者临床血清指标CA125、CA153、CRP/ALB水平均呈正相关性(P<0.05)。经ROC曲线分析可得,CA125、CA153、CRP/ALB诊断宫颈癌的截断值分别为38.50、37.24、1.40;单独及联合诊断的AUC值分别为0.800、0.857、0.803、0.980。结论 宫颈癌患者血清中CA125、CA153、CRP/ALB的比值水平明显升高,且CA125、CA153、CRP/ALB水平与患者临床分期及肿瘤直径均呈正相关,可用于辅助宫颈癌的诊断治疗,三项指标联合诊断价值更高。
Objective To explore the changes in cancer antigen 125(CA125),cancer antigen 153(CA153)and C-reactive protein-to-albumin ratio(CRP/ALB)in cervical cancer tissues and their correlation with tumor invasion and metastasis.Methods 158 cervical cancer patients were selected as the study group(n=158),and 76 healthy women who underwent physical examinations during the same period were selected as the control group(n=76).Compare the levels of CA125,CA153,CRP/ALB in the serum of 2 groups of study subjects,analyze the relationship between the levels of CA125,CA153,CRP/ALB in the serum of cervical cancer patients and clinical stage and pathological characteristics,use Spearman analysis to analyze the correlation between the levels of CA125,CA153,CRP/ALB in the serum of cervical cancer patients and clinical stage,and the diagnostic value of individual and combined detection of CA125,CA153,CRP/ALB ratio in the serum.Results The levels of CA125,CA153 and CRP/ALB ratio in the serum of the study group patients were significantly higher than those of the control group(P<0.05).The levels of 3 indicators in patients with tumor diameter≥4 cm were significantly higher than those in patients with diameter<4 cm(P<0.05);There is a positive correlation between clinical staging and three indicators,and the higher the staging,the higher the expression level(P<0.05);The levels of 3 indicators in adenocarcinoma patients were also significantly higher than those in squamous cell carcinoma patients(P<0.05);The 3 indicators of patients with lymph node metastasis were significantly higher than those without metastasis(P<0.05).According to Spearman correlation analysis,clinical staging,tumor diameter,and clinical serum indicators CA125,CA153,and CRP/ALB levels were positively correlated(P<0.05).According to ROC curve analysis,the cutoff values for diagnosing cervical cancer in CA125,CA153,and CRP/ALB were 38.50,37.24,and 1.40,respectively;The single and combined diagnosis of AUC values were 0.800,0.857,0.803,and 0.980,respectively.Conclusion The ratio levels of CA125,CA153,CRP/ALB in the serum of cervical cancer patients are significantly higher,and the levels of CA125,CA153,CRP/ALB are positively correlated with the clinical stage and tumor diameter of the patients.They can be used as auxiliary diagnostic and treatment for cervical cancer,and the combined diagnostic value of the 3 indicators is higher.
作者
贾彦巍
周筱
许词
JIA Yanwei;ZHOU Xiao;XU Ci(Nanyang Central Hospital,Nanyang,473000)
出处
《实用癌症杂志》
2023年第11期1805-1809,共5页
The Practical Journal of Cancer
