摘要
目的分析胎盘冻干粉对中老年失眠患者的治疗效果,以及其对心率变异性(HRV)的影响。方法选择2022年1月至2023年3月在东升医院进行治疗的122例女性失眠患者作为研究对象。采用随机数字表法将患者分为治疗组与对照组,每组61例。治疗组口服人类胎盘冻干粉颗粒进行干预,对照组口服淀粉填充胶囊进行干预,两组患者均连续治疗1个月。比较干预前后两组匹兹堡睡眠质量指数量表(PSQI)评分、PSQI改善率及HRV相关指标水平。结果干预后,治疗组睡眠质量、入睡时间、睡眠时间、睡眠效率、催眠药物使用、日间功能障碍评分及PSQI总分均低于干预前和对照组,而PSQI评分改善率(49.5%)明显高于对照组(2.1%),差异均有统计学意义(P<0.05)。干预后,两组患者的HRV相关指标略低于干预前,且治疗组略低于对照组,但差异均无统计学意义(P>0.05)。结论失眠患者口服胎盘冻干粉颗粒,可显著改善睡眠质量,且对患者HRV指标无明显影响。
Objective To analyze the therapeutic effect of lyophilized human placenta powder on middle-aged and elderly patients with insomnia,and its influence mechanism on heart rate variability(HRV).Methods A total of 122 female patients with insomnia who were treated in Dongsheng Hospital of Guangdong Province from January 2022 to March 2023 were selected as the research objects,who were divided into treatment group and control group according to random number table method,61cases in each group.The treatment group received lyophilized human placenta powder granules orally for intervention,while the control group took starch-filled capsules orally for intervention,and both groups were treated continuously for 1 month.The Pittsburgh Sleep Quality Index(PSQI)score,PSQI improvement rate and HRV-related indexes were compared between the two groups before and after intervention.Results After intervention,the scores of sleep quality,sleep latency,sleep duration,sleep efficiency,hypnotic drug use,daytime dysfunction and total PSQI score of the treatment group were lower than those of the pre-intervention and the control group,while the improvement rate of PSQI score(49.5%)of the treatment group was significantly higher than that of the control group(2.1%),and the differences were statistically significant(P<0.05).After intervention,the HRV-related indexes of the two groups were slightly lower than those before intervention,and which of the treatment group were slightly lower than those of the control group,but the differences were not statistically significant(P>0.05).Conclusion Oral administration of placenta lyophilized powder granules in patients with insomnia can significantly improve sleep quality,without significant effect on patients′HRV-related indexes.
作者
张雪
许超
朱燕
甘嘉亮
黄建国
陈国权
黄艳青
卜聿凡
张宗明
魏伟
赵自平
ZHANG Xue;XU Chao;ZHU Yan;GAN Jialiang;HUANG Jianguo;CHEN Guoquan;HUANG Yanqing;BU Yufan;ZHANG Zongming;WEI Wei;ZHAO Ziping(Department of Bone of Joint Rehabilitation,Dongsheng Hospital of Guangdong Province/Guangzhou Geriatric Rehabilitation Hospital,Guangzhou,Guangdong 510140,China;Guangzhou Civil Affairs Science and Technology Collaborative Innovation Center,Guangzhou,Guangdong 510700,China;Guangzhou Ruiboyin Health Technology Co.,Ltd.,Guangzhou,Guangdong 510663,China)
出处
《检验医学与临床》
CAS
2023年第21期3118-3121,共4页
Laboratory Medicine and Clinic
基金
广东省广州市科学技术局项目(202201011814)
广东省广州市民政科技协同创新中心项目(2023B04J0742)
广东省广州市民政局广州民政科技基金项目(2021MZK01/2021MZK11)。
关键词
胎盘
失眠
中老年
心率变异性
placenta
insomnia
middle-aged and elderly
heart rate variability
