摘要
目的抗疟药青蒿为菊科植物黄花蒿Artemisia annua L.的干燥地上部分。本文对近5年青蒿的化学成分及药理作用进行了全面、系统的综述,有助于更好地了解其药理机制,为未来的临床应用提供参考。方法在Google Scholar、Web of Science、Scifinder、PubMed、中国知网和万方等数据库中,对2018—2022年的相关文献进行了系统搜索并进行综述。结果近5年从青蒿中发现的化学成分主要包括倍半萜类、香豆素类、生物碱类及木脂素类,并且发现青蒿提取物及其单体化合物具有抗炎、抑菌、抗寄生虫、抗病毒、抗肿瘤及降糖等药理作用。结论青蒿是一种具有多种药理作用的中草药,可用于治疗某些慢性疾病,其药效物质基础和作用机制还需进一步深入研究。
Objective The antimalarial drug of Qinghao is the dry above ground part of Artemisia annua L..In this paper,the chemical components and pharmacological activities of Artemisia annua in recent 5 years were comprehensively and systematically reviewed.More studies on Artemisia annua will help us to better understand its pharmacological mechanisms and provide references for future clinical applications.Methods The relevant references in recent 5 years were systematically searched in databases such as Google Scholar,Web of Science,Scifinder,PubMed,CNKI and Wanfang.Results The main chemical components of Artemisia annua L.include sesquiterpenoids,coumarins,alkaloids and lignans.And Artemisia annua L.extract and its monomer compounds have pharmacological effects such as anti-inflammatory,anti-bacterial,anti-parasitic,anti-viral,anti-tumor,hypoglycemic and so on.Conclusion Artemisia annua L.is an herbal medicine with multiple pharmacological effects,and can be used for the treatment of certain chronic diseases.At the same time,further research is still needed on pharmacodynamic material basis and mechanism of action of Artemisia annua L..
作者
郭玉婷
郑海荣
张钰
吴清清
朱宇红
张新新
张继业
GUO Yuting;ZHENG Hairong;ZHANG Yu;WU Qingqing;ZHU Yuhong;ZHANG Xinxin;ZHANG Jiye(School of Pharmacy,Xi'an Jiaotong University,Xi'an 710061,China;Hangzhou Clinitech Biotechnology Limited Company,Hangzhou 310000,China)
出处
《西北药学杂志》
CAS
2023年第6期241-249,共9页
Northwest Pharmaceutical Journal
基金
国家自然科学基金项目(编号:81603267)
陕西省重点研发计划项目(编号:2020ZDLSF05-05)
陕西省中医药优秀中青年科技骨干人才计划、第四次全国中医药资源普查项目(编号:财社[2018]43号)
中医药传承创新暨“秦药”开发重点研究项目(编号:2021-02-ZZ-005)
“秦药”质量提升工程项目(编号:2021-QYZL-01)。
关键词
青蒿
化学成分
药理作用
Artemisia annua L.
chemical components
pharmacological activities
