摘要
目的:探讨^(99)Tc^(m)-MIBI SPECT/CT显像结合靶区/本底比值(target/non-target,T/NT)半定量分析对肺磨玻璃结节(ground-glass nodule,GGN)良恶性的诊断价值。方法:收集我院2015年至2022年经平扫CT诊断为GGN的患者68例,注射^(99)Tc^(m)-MIBI后用SPECT/CT分别采集早期(15 min)和延迟期(3 h)断层同机融合图像,计算早期摄取比值(early uptake ratio,EUR)及延迟摄取比值(delayed uptake ratio,DUR)。然后根据病理结果将病灶分为良、恶性两组,比较两组对^(99)Tc^(m)-MIBI SPECT/CT显像的EUR和DUR,并对其诊断效能进行ROC曲线分析。结果:^(99)Tc^(m)-MIBI SPECT/CT同机融合显像发现恶性病灶55例,良性病灶13例,其对GGN良恶性鉴别诊断的灵敏度为98.1%,特异度为75.0%,准确性为92.6%,阳性预测值为92.7%,阴性预测值为92.3%。EUR(t=-2.841,P=0.006)和DUR(t=-3.525,P=0.001)对GGN良恶性鉴别的差异分析均有统计学意义。当EUR≥1.315或DUR≥1.145时,为诊断恶性肺部病灶的最佳截断值,其对应的灵敏度、特异度分别为54.2%、100.0%和79.2%、83.3%,曲线下面积分别为0.771和0.799。结论:^(99)Tc^(m)-MIBI SPECT/CT显像结合T/NT半定量分析对GGN良恶性诊断可提供一定的参考价值。
Objective:To explore the diagnostic value of ^(99)Tc^(m)-MIBI SPECT/CT imaging combined with target/non-target(T/NT)semi-quantitative analysis in benign and malignant ground-glass nodules of lung.Methods:A total of 68 patients with ground-glass nodules by plain CT from 2015 to 2022 in our hospital were retrospectively collected.After injection of ^(99)Tc^(m)-MIBI,SPECT/CT was used to collect early(15 min)and delayed(3 h)tomography fusion images,respectively,and calculate early uptake ratio(EUR)and delayed uptake ratio(DUR)were calculated.Then,according to the pathological results,the lesions were divided into benign and malignant groups,and the EUR and DUR of ^(99)Tc^(m)-MIBI SPECT/CT imaging between the two groups were compared.Finally,ROC curve analysis was performed for their diagnostic efficacy.Results:The ^(99)Tc^(m)-MIBI SPECT/CT fusion imaging showed that 55 cases were malignant and 13 cases were benign.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of the ^(99)Tc^(m)-MIBI SPECT/CT fusion imaging were 98.1%,75.0%,92.6%,92.7%and 92.3%respectively in the differential diagnosis of benign and malignant ground-glass nodules.There were significant differences between EUR(t=-2.841,P=0.006)and DUR(t=-3.525,P=0.001)in the identification of benign and malignant ground-glass nodules.When EUR≥1.315 or DUR≥1.145,it was the best truncation value for the diagnosis of malignant lung lesions,and the corresponding sensitivity and specificity were 54.2%,100.0%,79.2%,83.3%,and the area under the curve were 0.771 and 0.799,respectively.Conclusion:^(99)Tc^(m)-MIBI SPECT/CT imaging combined with T/NT semi-quantitative analysis can provide a certain reference value for early diagnosis of benign and malignant ground-glass nodules of lung.
作者
靖功伟
王莉君
蒲盛蓝
王娇亚
李娅
任炳秀
JING Gongwei;WANG Lijun;PU Shenglan;WANG Jiaoya;LI Ya;REN Bingxiu(The First People's Hospital of Zunyi(The Third Affiliated Hospital of Zunyi Medical University),Guizhou Zunyi 563000,China)
出处
《现代肿瘤医学》
CAS
北大核心
2023年第21期4015-4019,共5页
Journal of Modern Oncology
基金
贵州省基础研究计划(自然科学类)项目(编号:黔科合基础〔2019〕1325号)
贵州省卫生健康委科学技术基金项目(编号:gzwjkj2020-1-001)。
关键词
^(99)Tc^(m)-MIBI
SPECT/CT
T/NT半定量分析
肺磨玻璃结节
ROC曲线
^(99)Tc^(m)-methoxyisobutyl isonitrile
single-photon emission-computed tomography/computed tomography
T/NT semi-quantitative analysis
ground-glass nodule of lung
receiver operating characterstic curve
