摘要
肾上腺髓质素(adrenomedullin,ADM)属于降钙素基因相关肽家族的一种降压和血管扩张肽。其本身不会致癌,但它可以通过不同的机制促进其进展。本综述就ADM的生理功能、对肿瘤的发生发展的作用、肿瘤微环境(tumor microenvironment,TME)中动态和多样化的免疫成分及ADM对TME的调节作用加以讨论。阐述了ADM在诱导肿瘤血管生成、促进肿瘤细胞的增殖、转移和侵袭、抗细胞凋亡中的重要作用。ADM被证明在多种肿瘤组织和细胞中高表达,是促进肿瘤进展中一个关键的作用因子。不但影响实体瘤细胞本身的恶性生长过程,而且会影响TME中的免疫细胞和基质等,营造一个适宜肿瘤细胞生存的微环境,促进了肿瘤的发生发展。
Adrenomedullin(ADM)is a antihypertensive and vasodilator peptide belonging to calcitonin gene-related peptide family.It does not cause cancer by itself,but it can promote its progress through different mechanisms.In this review,the physiological function of ADM,its role in the occurrence and development of tumor,the dynamic and diverse immune components in tumor microenvironment(TME)and the regulatory effect of ADM on TME were discussed.This paper expounds the important role of ADM in inducing tumor angiogenesis,promoting the proliferation,metastasis and invasion of tumor cells,and resisting apoptosis.ADM has been proved to be highly expressed in various tumor tissues and cells,and it is a key factor in promoting tumor progression.It not only affects the malignant growth process of solid tumor cells,but also affects the immune cells and matrix in TME,creating a microenvironment suitable for the survival of tumor cells and promoting the occurrence and development of tumor.
作者
潘美竹
张颐
PAN Meizhu;ZHANG Yi(Department of Gynecology,the First Hospital of China Medical University,Liaoning Shenyang 110001,China)
出处
《现代肿瘤医学》
CAS
北大核心
2023年第21期4067-4072,共6页
Journal of Modern Oncology
基金
国家卫生健康委医药卫生科技发展研究中心(编号:HDSL202003005)
辽宁省应用基础研究计划(编号:2022JH2/101300039)
辽宁省沈阳市科技计划(编号:22-321-33-08)。
关键词
肾上腺髓质素
生理功能
肿瘤发生发展
肿瘤微环境
adrenomedullin
physiological function
the occurrence and development of tumors
tumor microenvironment
