摘要
目的:探讨急性缺血性脑卒中患者血清硫氧化还原蛋白2(Txn2)、过氧化还原酶6(Prdx6)水平与病情及治疗结局的相关性。方法:抽取2020年10月至2022年10月濮阳市安阳地区医院收治的急性缺血性脑卒中患者157例,采用酶联免疫吸附法检测血清Txn2、Prdx6水平。根据美国国立卫生研究院卒中量表(NIHSS)评分将其分为轻度组(NIHSS评分<4分,67例)、中度组(NIHSS评分4~15分,51例)、重度组(NIHSS评分>15分,39例)。连续随访半年后,根据改良Rankin量表(mRS)评分将其分为预后良好组(mRS评分≤2分,112例)和预后不良组(mRS评分>3分,45例)。采用曲线下面积(AUC)评估血清Txn2、Prdx6水平对急性缺血性脑卒中患者预后的预测价值。结果:血清Txn2、Prdx6水平随着患者病情加重逐渐降低(轻度组>中度组>重度组),P<0.05。预后良好组患者血清Txn2、Prdx6水平高于预后不良组(P<0.05)。血清Txn2、Prdx6预测急性缺血性脑卒中患者预后的AUC(95%CI)分别为0.752(0.701~0.803)、0.849(0.798~0.900),截点值分别为4.48 ng/ml、61.42 pg/ml,特异度分别为57.03%、64.59%,灵敏度分别为91.46%、91.46%;Txn2与Prdx6联合检测的AUC(95%CI)为0.902(0.851~0.953),特异度为85.46%,灵敏度为87.21%。结论:血清Txn2、Prdx6水平下调与急性缺血性脑卒中患者病情加重和预后不良有关,两者可作为预测急性缺血性脑卒中患者预后的潜在血清标志物。
Objective To investigate the correlation of the levels of serum thioredoxin 2(Txn2)and peroxiredoxin 6(Prdx6)with pathogenetic condition and treatment outcome in patients with acute ischemic stroke.Methods A total of 157 patients with acute ischemic stroke admitted to Anyang District Hospital of Puyang from October 2020 to October 2022 were selected.The levels of serum Txn2 and Prdx6 were detected by enzyme linked immunosorbent assay.According to the National Institutes of Health stroke scale(NIHSS)score,the selected patients were divided into mild group(NIHSS score<4,67 cases),moderate group(NIHSS score 4-15,51 cases)and severe group(NIHSS score>15,39 cases).According to the modified Rankin scale(mRS)score,they were divided into good prognosis group(mRS score≤2,112 cases)and a poor prognosis group(mRS score>3,45 cases)after 6 months of continuous follow-up.The area under the curve(AUC)was used to evaluate the predictive value of the levels of serum Txn2 and Prdx6 on the prognosis of patients with acute ischemic stroke.Results The levels of serum Txn2 and Prdx6 gradually decreased with the aggravation of the disease(mild group>moderate group>severe group),P<0.05.The levels of serum Txn2 and Prdx6 in the good prognosis group were higher than those in the poor prognosis group(P<0.05).The area under the curve(AUC)95%confidence interval(CI)of Txn2 and Prdx6 in predicting prognosis of acute ischemic stroke were 0.752(0.701-0.803)and 0.849(0.798-0.900),respectively,the cut-off value of them were 4.48 ng/ml and 61.42 pg/ml,the specificity of them were 57.03%,and 64.59%,the sensitivity of them were 91.46%and 91.46%.The AUC(95%CI)of combined detection of Txn2 and Prdx6 was 0.902(0.851-0.953),the specificity was 85.46%,and the sensitivity was 87.21%.Conclusions The decrease of levels of serum Txn2 and Prdx6 is related to the exacerbation and poor prognosis of patients with acute ischemic stroke.Both indicators can be used as potential serum markers to predict the prognosis of patients with acute ischemic stroke.
作者
魏瑞花
洪丽
Wei Ruihua;Hong Li(Department of Neurology,Anyang District Hospital of Puyang,Anyang 455000,China)
出处
《中国实用医刊》
2023年第17期25-28,共4页
Chinese Journal of Practical Medicine
