摘要
目的:探讨利拉鲁肽联合短期胰岛素强化治疗对初诊肥胖2型糖尿病(T2DM)患者的效果。方法:抽取2018年1月至2022年1月于平煤神马医疗集团总医院初诊为肥胖T2DM的患者60例,采用随机数字表法分为对照组和研究组,每组30例。对照组采用二甲双胍联合短期胰岛素强化治疗,研究组采用利拉鲁肽联合短期胰岛素强化治疗。比较两组治疗前后体质指数(BMI)、腰围、内脏脂肪面积、血糖指标[空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)]、胰岛素用量、血糖达标时间及不良反应发生率。结果:治疗后,研究组BMI、腰围、内脏脂肪面积均小于对照组(P均<0.05);研究组FPG、2hPG、HbA1c水平低于对照组(P<0.05);研究组胰岛素用量少于对照组、血糖达标时间短于对照组(P<0.05)。研究组不良反应发生率(13.33%,4/30)与对照组(16.67%,5/30)比较差异未见统计学意义(P>0.05)。结论:利拉鲁肽联合短期胰岛素强化治疗初诊肥胖T2DM效果显著,可降低患者体质量,减少内脏脂肪面积,有效控制机体血糖水平,减少胰岛素用量。
Objective To investigate the therapeutic effect of liraglutide combined with short-term intensive insulin therapy on newly diagnosed obese patients with type 2 diabetes mellitus(T2DM).Methods A total of 60 patients with obese T2DM who were newly diagnosed in the General Hospital of Pingmei Shenma Group from January 2018 to January 2022 were selected,and they were divided into control group and study group by random number table method,with 30 cases in each group.The control group was treated with metformin combined with short-term intensive insulin therapy,while the study group was treated with liraglutide combined with short-term intensive insulin therapy.The body mass index(BMI),waist circumference,visceral fat area,blood glucose indexes,including fasting plasma glucose(FPG),2-hour postprandial blood glucose(2hPG)and hemoglobin A1c(HbA1c)of the two groups were compared before and after treatment.The insulin dosage,time for reaching blood glucose standards,and incidence of adverse reactions were compared between the two groups.Results After treatment,the BMI,waist circumference,and visceral fat area of the study group were smaller than those of the control group(all P<0.05);the levels of FPG,2hPG and HbA1c in the study group were lower than those in the control group(P<0.05);The insulin dosage in the study group was less than that in the control group,and the time for reaching blood glucose standards was shorter than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the study group(13.33%,4/30)and the control group(16.67%,5/30),P>0.05.Conclusions Liraglutide combined with short-term intensive insulin therapy has a significant effect in the treatment of newly diagnosed obese T2DM,which can reduce the body weight of patients,reduce the visceral fat area,effectively control blood glucose level,reduce insulin dosage.
作者
杨鹿鸣
马艳庆
李丰果
Yang Luming;Ma Yanqing;Li Fengguo(Department of Endocrinology,General Hospital of Pingmei Shenma Group,Pingdingshan 467000,China)
出处
《中国实用医刊》
2023年第17期91-94,共4页
Chinese Journal of Practical Medicine
关键词
2型糖尿病
肥胖
利拉鲁肽
短期胰岛素
血糖水平
Diabetes mellitus,type 2
Obesity
Liraglutide
Short-term insulin
Blood glucose level
