摘要
目的系统评价凉血五花汤治疗面部激素依赖性皮炎(FHDD)的有效性和安全性。方法计算机检索美国国立医学图书馆全文数据库(PubMed)、生物医学文献数据库(Embase)、The Cochrane图书馆、中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方数据库和维普中文期刊数据库,检索时限为自数据库建立至2021年4月30日,筛选凉血五花汤治疗FHDD的随机对照试验(RCT)。由2名研究者独立筛选文献、提取资料及评价纳入研究的偏倚风险后,采用RevMan5.4软件进行数据分析。结果共纳入6项RCT,共计511例FHDD患者。Meta分析结果显示,与常规药物治疗对照组比较,联合凉血五花汤治疗研究组FHDD能够提高临床愈显率[相对危险度(RR)=1.53,95%可信区间(95%CI)为(1.17,2.00),P=0.002],改善皮肤红斑[均数差(MD)=51.47,95%CI(21.48,81.45),P=0.0008],降低经皮水分丢失[MD=6.76,95%CI(6.34,7.17),P<0.00001];但未增加不良反应发生率的风险[RR=1.08,95%CI(0.59,1.98),P=0.80]。结论凉血五花汤加减治疗FHDD能够提高临床愈显率、改善面部红斑、减少经皮水分丢失,是一种安全有效的治疗方法。
Objective In order to systematically review the efficacy and safety of Liangxue Wuhua decoction for facial hormone-dependent dermatitis(FHDD).Methods PubMed,Excerpta Medica database(EMbase)and the Cochrane were searched by computer Library,Chemical-Biological Munitions(CBM),China National Knowledge Infrastructure(CNKI),Wanfang and VIP databases were searched from the establishment of the database to April 30,2021.Randomized controlled trials(RCTs)of Liangxue Wuhua decoction in the treatment of FHDD were screened.Two researchers independently screened the literature,extracted the data and evaluated the risk of bias in the included studies.Revman 5.4 was used for data analysis.Results Six RCTs involving 511 patients with FHDD were included.The Meta results showed that the effective rate of the Liangxue Wuhua decoction treatment group was significantly higher than that of the routine drug therapy control group[relative risk(RR)=1.53,95%credibility interval(CI)was(1.17,2.00),P=0.002],the amount of skin erythema[mean difference(MD)=51.47,95%CI(21.48,81.45),P=0.0008],and the improvement degree of percutaneous water loss[MD=6.76,95%CI(6.34,7.17),P<0.00001],and there were no significant differences in the incidence of adverse reactions between two groups[RR=1.08,95%CI(0.59,1.98),P=0.80].Conclusion The modified Liangxue Wuhua decoction may improve the effective rate of patients with FHDD,improve facial erythema,and reduce transdermal water loss,which is a safe and effective treatment.
作者
周李佳铭
李玉梅
周冬梅
Zhou Lijiaming;Li Yumei;Zhou Dongmei(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)
出处
《中国中西医结合皮肤性病学杂志》
CAS
2023年第5期425-430,共6页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
基金
北京市医院管理中心重点医学专业发展计划项目(编号:ZYLX202115)。
关键词
凉血五花汤
面部激素依赖性皮炎
系统评价
META分析
Liangxue Wuhua decoction
Facial hormone-dependent dermatitis
System evaluation
Meta-analysis
