摘要
目的 对莫诺苷的药理学作用及分子机制进行分析总结,为以后深入研究及临床开发应用提供有效的参考。方法 全面检索中国知网、万方数据知识服务平台、维普网、PubMed、Web of Science等各大中英文数据库自建库至2022年6月发表的莫诺苷相关文献,对其药理作用归纳整理。结果 莫诺苷作为山茱萸的主要活性成分之一,具有多种药理作用。作用于神经系统,能够促进神经再生与修复、抗氧化应激、减少神经细胞凋亡、抑制炎症反应、促进脑血管新生、抗血小板聚集、降低血黏度、抗凝及激活Wnt信号通路,并且具有心脏保护,骨关节保护,以及治疗消化系统炎症与糖尿病肾病等作用。结论 莫诺苷药理学作用较为丰富,但深入研究和人体内药理研究尚显不足,需加以进一步深入探究和临床试验验证。
Objective This review was conducted to analyze and summarize the pharmacological effects and molecular mecha-nisms of morroniside,and to provide a useful reference for further research,clinical development,and application.s Methods In re-gard to that,Chinese and English databases referencing the literature on morroniside,including China National Knowledge Infra-structure(CNKI),Wanfang Data Knowledge Service Platform,Chongqing VIP(QVIP),PubMed and Web of Science were compre-hensively searched from their inception to June 2022,and its pharmacological effects were summarized and sorted.s Results It is reviewed that morroniside,one of the chief active components of Shanzhuyu(Corni Fructus),possesses various pharmacological effects.Acting on the nervous system,it can promote nerve regeneration and repair,reduce neuronal apoptosis,inhibit inflammato-ry reaction,promote cerebral angiogenesis,reduce blood viscosity,anticoagulate and activate Wnt signaling pathway and has the effects of antioxidant stress and anti platelet aggregation.It also has the functions of heart protection,bone and joint protection and treatment of digestive system inflammation and diabetes nephropathy.n Conclusion The pharmacological effects of morroniside are abundant,but the in-depth study and pharmacological study in the human body are insufficient,and need to be further ex-plored and verified by clinical trials.
作者
李毛
杨东东
徐江雁
LI Mao;YANG Dongdong;XU Jiangyan(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China;The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan,China;Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2023年第10期70-75,共6页
Chinese Archives of Traditional Chinese Medicine
基金
国家重点研发计划(2020YFE0201800)
国家自然科学基金项目(82004019,82174267)。
关键词
莫诺苷
药理作用
研究进展
morroniside
pharmacological action
research progress
