摘要
帕金森病(PD)是第二大常见的神经系统退行性疾病,其诊断主要依赖详细的病史及体格检查。PD的早期诊断准确性亟待提高。生物标志物是PD早期诊断的重要工具,文章对PD早期诊断的临床、影像、生化、遗传、病理等生物标志物进行总结阐述,并对其未来发展方向进行讨论。
Parkinson disease(PD),the second most prevalent neurodegenerative disorder,is predominantly diagnosed depending on comprehensive medical history and physical examination.However,the accuracy of early diagnosis of PD needs to be improved.Biomarkers play a crucial role in the early diagnosis of PD.Here we summarized diverse biomarkers that aid early diagnosis of PD,including clinical,imaging,biochemical,genetic,and pathological biomarkers,and explored future directions in this field.
作者
张亦弛
刘军
ZHANG Yi-chi;LIU Jun(Department of Neurology,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China)
出处
《中国实用内科杂志》
CSCD
北大核心
2023年第10期812-821,共10页
Chinese Journal of Practical Internal Medicine
基金
国家自然科学基金(82071415,82230040)。
