摘要
目的研究氨茶碱联合盐酸氨溴索治疗急性喘息性支气管炎的临床疗效及对炎性指标的影响。方法选取2019年5月-2021年7月泰和县人民医院诊治的60例急性喘息性支气管炎患儿为研究对象,采用随机数字表法分为对照组(n=30)和观察组(n=30)。对照组采用盐酸氨溴索治疗,观察组在对照组基础上联合氨茶碱治疗,比较两组临床疗效、炎性指标[C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)]、临床症状消失时间、不良反应发生情况。结果观察组治疗总有效率为93.33%,高于对照组的80.00%(P<0.05);两组治疗后CRP、TNF-α、IL-8水平低于治疗前,且观察组低于对照组(P<0.05);观察组喘息、咳嗽、肺部湿啰音消失时间短于对照组(P<0.05);观察组不良反应发生率为6.67%,低于对照组的20.00%(P<0.05)。结论氨茶碱联合盐酸氨溴索治疗急性喘息性支气管炎具有较理想的临床效果,可抑制炎症反应,改善临床症状,降低不良反应发生几率。
Objective To study the clinical efficacy of aminophylline combined with ambroxol hydrochloride in the treatment of acute asthmatic bronchitis and its effect on inflammatory indexes.Methods A total of 60 children with acute asthmatic bronchitis diagnosed and treated in Taihe County People's Hospital from May 2019 to July 2021 were selected as the research objects.They were divided into control group(n=30)and observation group(n=30)by random number table method.The control group was treated with ambroxol hydrochloride,and the observation group was treated with aminophylline on the basis of the control group.The clinical efficacy,inflammatory indexes[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)],disappearance time of clinical symptoms and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33%,which was higher than 80.00%in the control group(P<0.05).After treatment,the levels of CRP,TNF-αand IL-8 in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).The disappearance time of wheezing,cough and lung wet rales in the observation group was shorter than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was 6.67%,which was lower than 20.00%in the control group(P<0.05).Conclusion Aminophylline combined with ambroxol hydrochloride has an ideal clinical effect in the treatment of acute asthmatic bronchitis,which can inhibit inflammatory reaction,improve clinical symptoms and reduce the incidence of adverse reactions.
作者
周青梅
周春平
ZHOU Qing-mei;ZHOU Chun-ping(Department of Pediatrics,Taihe County People's Hospital,Taihe 343700,Jiangxi,China;Department of Pathology,Ji'an Central People's Hospital,Ji'an 343100,Jiangxi,China)
出处
《医学信息》
2023年第22期113-115,共3页
Journal of Medical Information
关键词
氨茶碱
盐酸氨溴索
急性喘息性支气管炎
Aminophylline
Ambroxol hydrochloride
Acute asthmatic bronchitis
