摘要
目的探讨克霉唑阴道片联合氟康唑治疗复发性霉菌性阴道炎的效果。方法选取本院60例复发性霉菌性阴道炎患者为研究对象,根据抽签法分为两组,各30例。参照组应用克霉唑阴道片治疗,试验组应用克霉唑阴道片联合氟康唑治疗。比较两组的治疗效果、血清细胞因子、生活质量。结果试验组治疗总有效率为86.67%,高于参照组的60.00%,差异有统计学意义(P<0.05);治疗后,试验组白细胞介素-8、白细胞介素-6、肿瘤坏死因子水平均低于参照组,差异有统计学意义(P<0.05);治疗后,试验组生活质量评分高于参照组,差异有统计学意义(P<0.05)。结论克霉唑阴道片联合氟康唑治疗复发性霉菌性阴道炎,治疗效果显著,能明显改善患者的血清细胞因子水平,提高生活质量,可在临床推广。
Objective To explore the efficacy of clotrimazole vaginal tablets combined with fluconazole in the treatment of recurrent fungal vaginitis.Methods Sixty patients with recurrent fungal vaginitis in our hospital were selected as the research subjects,and were divided into two groups according to the method of drawing lots,with 30 cases in each group.The reference group was treated with clotrimazole vaginal tablets,while the experimental group was treated with clotrimazole vaginal tablets combined with fluconazole.The therapeutic effects,serum cytokines,and quality of life of the two groups were compared.Results The total effective rate of the experimental group was 86.67%,which was higher than 60.00%of the reference group,with a statistically significant difference(P<0.05);After treatment,the levels of interleukin-8,interleukin-6,and tumor necrosis factor in the experimental group were significantly lower than those in the control group(P<0.05);After treatment,the quality of life score of the experimental group was higher than that of the reference group,and the difference was statistically significant(P<0.05).Conclusion The combination of clotrimazole vaginal tablets and fluconazole has a significant therapeutic effect on recurrent fungal vaginitis,which can significantly improve the serum cytokine levels and quality of life of patients,and can be widely promoted in clinical practice.
作者
张敬茹
Zhang Jingru(Department of Obstetrics and Gynecology,Inner Mongolia Chifeng Songshan Hospital,Chifeng 024001,China)
出处
《实用妇科内分泌电子杂志》
2023年第19期78-80,共3页
Electronic Journal of Practical Gynecological Endocrinology
关键词
克霉唑阴道片
氟康唑
复发性霉菌性阴道炎
治疗效果
Clotrimazole vaginal tablets
Fluconazole
Recurrent fungal vaginitis
Treatment effect
