摘要
目的分析生长抑素联合内镜下食管静脉曲张套扎术(EVL)治疗肝硬化食管静脉曲张破裂出血(EVB)的临床效果。方法选择2019年1月至2022年6月收治的200例肝硬化EVB患者,随机将其分为对照组和观察组,各100例。对照组在对症支持基础上实施内镜下EVL治疗,观察组在对照组基础上给予生长抑素治疗。比较两组的治疗效果。结果观察组的治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。观察组的输血总量少于对照组,止血时间、静脉曲张恢复时间、住院时间短于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的门静脉血流量(PVF)、脾静脉血流量(SVBF)、肝静脉压力梯度(HVPG)及红细胞计数(RBC)比较,差异无统计学意义(P>0.05);治疗后,观察组的PVF、SVBF、HVPG显著低于对照组,RBC显著高于对照组,差异具有统计学意义(P<0.05)。两组的并发症总发生率比较,差异无统计学意义(P>0.05)。结论生长抑素联合EVL治疗肝硬化EVB的效果较佳,可缩短患者的止血时间、减少输血量,改善血流指标,且不会增加并发症发生率,具有重要的临床应用价值。
Objective To analyze the clinical effect of somatostatin combined with endoscopic variceal ligation(EVL)in the treatment of esophageal variceal bleeding(EVB)due to cirrhosis.Methods From January 2019 to June 2022,200 cirrhosis patients with EVB were selected and randomly divided into control group and observation group,with 100 cases in each group.The control group was treated with EVL on the basis of symptomatic support,and the observation group was treated with somatostatin on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).The total amount of blood transfusion in the observation group was less than that in the control group,the hemostasis time,varicose vein recovery time and hospitalization time were shorter than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in portal venous flow(PVF),splenic venous blood flow(SVBF),hepatic venous pressure gradient(HVPG)and red blood cell(RBC)between the two groups(P>0.05);after treatment,the PVF,SVBF and HVPG in the observation group were significantly lower than those in the control group,the RBC was significantly higher than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion The somatostatin combined with EVL in the treatment of EVB due to cirrhosis has better effect,which can shorten the hemostasis time,reduce the amount of blood transfusion,improve the blood flow indexes,and will not increase the incidence of complications,it has important clinical application value.
作者
王明荣
WANG Mingrong(Digestive Department,Zhangye People's Hospital Affiliated to Hexi University,Zhangye 734000,China)
出处
《临床医学研究与实践》
2023年第33期91-94,共4页
Clinical Research and Practice
