摘要
目的探讨血清C反应蛋白(CRP)、淀粉酶(AMY)、脂肪酶(LPS)联合检测对急性胰腺炎(AP)的诊断价值。方法选取2020年6月至2021年6月收治的300例AP患者为病例组,同期选取300例健康体检者为对照组。比较对照组与病例组的CRP、AMY、LPS水平;比较病例组中轻症与重症患者不同时间的CRP、AMY、LPS水平;比较CRP、AMY、LPS单独及联合检测对AP的诊断效能;分析CRP、AMY、LPS与重症组患者预后的相关性。结果病例组的CRP、AMY、LPS水平均高于对照组(P<0.05)。轻症组与重症组的CRP、AMY、LPS水平在入院48 h达到峰值,入院72 h逐渐降低;入院时及入院24、48、72 h,重症组的CRP、AMY、LPS水平均高于轻症组(P<0.05)。CRP、AMY、LPS联合检测对AP的诊断灵敏度、特异度、准确度、阴性预测值、阳性预测值均高于单独检测(P<0.05)。死亡组的CRP、AMY、LPS水平高于存活组(P<0.05);Spearman相关性分析结果显示,CRP、AMY、LPS与重症组患者的预后呈显著负相关(P<0.05)。结论血清CRP、AMY、LPS联合检测对AP具有较高的诊断价值,能够有效预测患者的病情严重程度,对重症患者有一定的早期诊断价值。
Objective To explore the value of combined detection of serum C-reactive protein(CRP),amylase(AMY)and lipase(LPS)in the diagnosis of acute pancreatitis(AP).Methods A total of 300 AP patients admitted from June 2020 to June 2021 were selected as case group,and 300 healthy subjects were selected as control group during the same period.The levels of CRP,AMY and LPS were compared between the control group and the case group;the levels of CRP,AMY and LPS in mild and severe cases in the case group at different time were compared;the diagnostic efficacy of CRP,AMY and LPS alone and in combination for AP were compared;the correlation between CRP,AMY,LPS and prognosis of patients in the severe group was analyzed.Results The levels of CRP,AMY and LPS in the case group were higher than those in the control group(P<0.05).The levels of CRP,AMY and LPS in the mild and severe groups reached the peak at 48 h after admission,and gradually decreased at 72 h after admission;at admission and at 24,48,72 h after admission,the levels of CRP,AMY and LPS in the severe group were higher than those in the mild group(P<0.05).The diagnostic sensitivity,specificity,accuracy,negative predictive value and positive predictive value of combined detection of CRP,AMY and LPS for AP were higher than those of single detection(P<0.05).The levels of CRP,AMY and LPS in the death group were higher than those in the survival group(P<0.05);Spearman correlation analysis results showed that CRP,AMY and LPS were negatively correlated with the prognosis of patients in the severe group(P<0.05).Conclusion The combined detection of serum CRP,AMY and LPS has high diagnostic value for AP,which can effectively predict the severity of patients'disease,and has certain early diagnostic value for severe patients.
作者
李艳
杨倩
苏莹
LI Yan;YANG Qian;SU Ying(Laboratory Department,the People's Hospital of Nanzheng District,Hanzhong 723100;Laboratory Department,Shaanxi Provincial People's Hospital,Xi'an 710068,China)
出处
《临床医学研究与实践》
2023年第33期115-118,共4页
Clinical Research and Practice
