摘要
目的探讨中医药内外三联法治疗膝关节骨性关节炎的临床有效性及安全性。方法回顾性选取2020年2月—2022年2月万安县中医院膝关节骨性关节炎患者100例,依据治疗方法分为中医药内外三联法治疗组(内外三联法组)、西医常规性治疗组(常规性治疗组),各50例。统计分析2组中医证候积分、血清炎症因子水平、膝关节功能、临床疗效、不良反应发生情况、复发情况。结果治疗后,内外三联法组患者的中医证候积分及血清一氧化氮(NO)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)水平均低于常规性治疗组(P<0.05)。内外三联法组关节僵硬、疼痛、机体功能评分及西大略和麦克马斯特大学骨性关节炎指数(WOMAC)评分总分均低于常规性治疗组(P<0.05)。内外三联法组治疗总有效率96.00%(48/50)高于常规性治疗组的82.00%(41/50)(P<0.05)。内外三联法组不良反应发生率6.00%(3/50)低于常规性治疗组的20.00%(10/50)(P<0.05)。内外三联法组复发率2.00%(1/50)低于常规性治疗组的16.00%(8/50)(P<0.05)。结论中医药内外三联法治疗膝关节骨性关节炎的临床有效性及安全性较西医常规性治疗高。
Objective To explore the clinical efficacy and safety of internal and external triple therapy of traditional Chinese medicine in the treatment of knee osteoarthritis.Methods A total of 100 patients with knee joint osteoarthritis in Wan’an Hospital of Traditional Chinese Medicine from February 2020 to February 2022 were retrospectively selected and divided into internal and external triple therapy of traditional Chinese medicine group(internal and external triple therapy group)and Western medicine conventional therapy group(conventional therapy group)according to treatment methods,with 50 cases in each.TCM syndrome score,serum inflammatory factor level,knee joint function,clinical efficacy,occurrence and recurrence of adverse reactions were statistically analyzed in the two groups.Results After treatment,the TCM syndrome scores and serum levels of nitric oxide(NO),tumor necrosis factor-α(TNF-α)and interleukin-1(IL-1)of patients in the internal and external triple therapy group were lower than those in the conventional treat⁃ment group(P<0.05).Joint stiffness,pain,body function scores and the total score of Western Ontario and McMaster University Osteo⁃arthritis Index(WOMAC)in the internal and external triple therapy group were lower than those in the conventional treatment group(P<0.05).The total effective rate in the internal and external triple therapy group was 96.00%(48/50),which was higher than that in the conventional treatment group82.00%(41/50)(P<0.05).The incidence of adverse reactions in the internal and external triple therapy group was 6.00%(3/50),which was lower than that in the conventional treatment group(20.00%,10/50)(P<0.05).The recurrence rate of the internal and external triple therapy group was 2.00%(1/50),which was lower than that of the conventional treatment group(16.00%,8/50)(P<0.05).Conclusion The clinical efficacy and safety of internal and external triple therapy of traditional Chinese medicine in the treatment of knee osteoarthritis is higher than that of conventional Western medicine.
作者
邱辉林
朱美兰
周德胜
QIU Huilin;ZHU Meilan;ZHOU Desheng(Department of Rehabilitation,Wan’an Hospital of Traditional Chinese Medicine,Jiangxi Province,Wan’an 343800,China;Department of Pharmacy,Wan’an Hospital of Traditional Chinese Medicine,Jiangxi Province,Wan’an 343800,China)
出处
《中国中医药现代远程教育》
2023年第24期103-105,共3页
Chinese Medicine Modern Distance Education of China
关键词
痹证
膝关节骨性关节炎
中医药内外三联法
arthralgia syndrome
knee osteoarthritis
internal and external triple therapy of traditional Chinese medicine
