摘要
目的:通过应用肌骨超声探讨白芍总苷(total glucosides of paeony,TGP)对类风湿关节炎(rheuma-toid arthritis,RA)患者骨破坏的临床疗效。方法:选取2021年7月至2023年7月张家口市第二医院住院及门诊符合诊断标准的类风湿关节炎患者56例,按随机数字表法分为治疗组和对照组各28例,对照组给予口服甲氨蝶呤,治疗组在此基础上加用白芍总苷,疗程12周,观察治疗前后两组患者红细胞沉降率(erythro-cyte sedim entation rate,ESR)、C-反应蛋白(C-reaction protein,CRP)等炎症指标,通过ACR20/50/70评价两组患者治疗后的疗效,肌骨超声检测患者关节滑膜增生、滑膜内血流信号、骨侵蚀及关节积液等。比较两组患者治疗前后及组间上述指标的变化。结果:①治疗组ACR20/50/70达标率高于对照组,两组患者的炎性指标ESR、CRP均较治疗前降低,但治疗组明显高于对照组;②与治疗前相比,两组患者滑膜增生、关节腔积液、滑膜血流均降低,治疗组降低较为明显,差异有统计学意义,治疗前后骨破坏差异无统计学意义。结论:白芍总苷可提高达标率,减轻类风湿关节炎患者急性期症状,抑制炎症反应,保护关节,防治R A骨破坏,延缓类风湿关节炎病程进展。
Objective:To investigate the clinical effect of TGP on bone destruction in.patients with Rheumatoid Arthritis(RA)by musculoskeletal ultrasound.Methods:A total of 56 patients with rheumatoid arthritis who were admitted to our hospital from 2021-07 to 2023-07 and were randomly divided into the treatment group and the control group with 28 patients in each group according to the random number table met hod.The control group was treated with methotrexate,and the treatment group was treated with methotrexate and TGP for 12 weeks.Inflammatory indicators such as ESR and CRP were observed before and after treatment.The Clinical effect of the two groups was evaluated by ACR20/50/70.Musculo-skeletal ultrasound was used to detect synovial,the synovium blood flow signal,bone erosion and joint effusion.The above indexes were compared between the two groups before and after treatment.Results:①The control rate of ACR20/50/70 in the treatment group was high-er than that in the control group,and the inflammatory indexes ESR and CRP in both groups were lower than before trea tment,but the treat ment group was significantly higher than the control group.②Compared with before treatment,synovial,articular effusion and synovial blood flow were all decreased in 2 groups,and the decrease was more obvious in the treat-ment group,the difference was statistically significant,while there was no statistically sig-nificant difference in bone destruction before and after treatment.Conclusion:TGP can im-prove the standard reaching rate,reduce the symptoms of patients with rheumatoid arthritis.in the acute phase,inhibit inflammatory response,protect joints,prevent RA bone damage.and delay the progression of rheumatoid arthritis.
作者
刘红杰
皮天龙
王钢
荣铁成
穆桂瑶
田杰祥
LIU Hong-jie;PI Tian-long;WANG Gang;RONG Tie-cheng;MU Gui-yao;TIAN Jie-xiang(The Second Hospital of Zhangjiakou,Zhangjiakou,075000,China;The Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou,730000,China)
出处
《神经药理学报》
2023年第2期30-35,40,共7页
Acta Neuropharmacologica
基金
国家自然科学基金项目(No.81960832)
河北省中医药管理局项目(No.2022530)。
