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Modular synthesis of 1,4-diketones through regioselective bis-acylation of olefins by merging NHC and photoredox catalysis

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摘要 Efficient and modular synthesis of structurally diverse 1,4-diketones from readily available building blocks represents an essential but challenging task in organic chemistry.Herein,we report a multi-component,regioselective bis-acylation of olefins by merging NHC organocatalysis and photoredox catalysis.With this protocol,a broad range of 1,4-diketones could be rapidly assembled using bench-stable feedstock materials.The robustness of this method was further evaluated by sensitivity screening,and good reproductivity was observed.Moreover,the diketone products could be readily converted into functionalized heterocycles,such as multi-substituted furan,pyrrole,and pyridazine.Mechanistic investigations shed light on the NHC and photoredox dual catalytic radical reaction mechanism.
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第11期169-174,共6页 中国化学快报(英文版)
基金 the National Natural Science Foundation of China(NSFC,Nos.22071011,21871031,22271028 and 82073998) Longquan Talents Program,the Science&Technology Department of Sichuan Province(Nos.2021YJ0404,2022JDRC0045 and 2023NSFSC1081) the innovative project of Chengdu University is gratefully acknowledged.
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