摘要
目的:观察电针对急性缺血性脑卒中(AIS)溶栓患者血清自噬因子及神经功能的影响。方法:选择104例AIS溶栓患者,按随机数字表法分为观察组和对照组各52例。5例受试者于研究过程脱落,实际完成病例数99例,其中观察组50例,对照组49例。对照组参考指南予常规治疗,观察组在对照组基础上给予电针疗法,连续治疗4周。评价2组临床疗效,比较2组治疗前后超敏C-反应蛋白(hs-CRP)、血管内皮生长因子(VEGF)、沉默信息调节因子1 (SIRT1) mRNA和自噬相关贝克林1 (Beclin1) mRNA水平,评价2组神经功能和生活质量。结果:观察组总有效率为94.00%,高于对照组71.43%(P<0.05)。治疗后,2组hs-CRP、VEGF水平较治疗前下降(P<0.05),SIRT1 mRNA较治疗前上升(P<0.05)。治疗后,观察组hs-CRP、VEGF、Beclin1 mRNA低于对照组,SIRT1 mRNA高于对照组(P<0.05)。治疗后,2组美国国立卫生研究院卒中量表(NIHSS)评分较治疗前降低(P<0.05);且观察组NIHSS评分低于对照组(P<0.05)。治疗后,2组脑卒中专用生活质量量表(SS-QOL)各项目评分均高于治疗前(P<0.05),且观察组体力、手功能、情绪、生活能力和社会活动评分均高于对照组(P<0.05)。结论:电针有助于改善AIS患者临床症状,改善细胞自噬及血管新生,恢复患者神经功能,提高日常生活能力和生活质量。
Objective:To observe the effect of electro-acupuncture on autophagy factors in serum and neurological function in patients with thrombolysis for acute ischemic stroke(AIS).Methods:A total of104 cases of patients with thrombolysis for AIS were selected and divided into the observation group and the control group according to the random number table method,with 52 cases in each group.Five subjects fell out during the research process,and the actual number of completed cases was 99,including50 cases in the observation group and 49 cases in the control group.The control group received routine treatment according to the guidelines,and the observation group received electro-acupuncture based on the treatment of the control group.Both groups were treated for four consecutive weeks.The clinical effects in the two groups were evaluated.The levels of high-sensitivity C-reactive protein(hs-CRP) and vascular endothelial growth factor(VEGF),as well as mRNA of silent information regulator 1(SIRT1) and autophagy-related gene Beclin-1(Beclin1) in the two groups were compared before and after treatment.The neurological function and quality of life were evaluated in the two groups.Results:The total effective rate was 94.00% in the observation group,higher than that of 71.43% in the control group(P<0.05).After treatment,the levels of hs-CRP and VEGF in the two groups were decreased when compared with those before treatment(P<0.05),and mRNA of SIRT1 was increased when compared with that before treatment(P<0.05).After treatment,the levels of hs-CRP and VEGF and mRNA of Beclin1 in the observation group were lower than those in the control group,and mRNA of SIRT1 was higher than that in the control group(P<0.05).After treatment,the scores of National Institutes of Health Stroke Scale(NIHSS) in the two groups were decreased when compared with those before treatment(P<0.05);and the NIHSS score in the observation group was lower than that in the control group(P<0.05).After treatment,the scores of each item on the Stroke Specific Quality of Life Scale(SS-QOL) in the two groups were higher than those before treatment(P<0.05),and the physical strength,hand function,emotion,life ability,and social activity scores in the observation group were higher than those in the control group(P<0.05).Conclusion:Electro-acupuncture is helpful to improve the clinical symptoms of AIS patients,improve autophagy and angiogenesis,restore neurological function of patients,and improve the ability of daily living and quality of life.
作者
苑翼楠
朱娴琼
徐颖
程南方
白雪
YUAN Yinan;ZHU Xianqiong;XU Ying;CHENG Nanfang;BAI Xue(The First Affiliated Hospital of Jinzhou Medical University,Jinzhou Liaoning 121000,China;Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510006,China;Foshan Hospital of Traditional Chinese Medicine,Foshan Guangdong 528000,China)
出处
《新中医》
CAS
2023年第19期201-205,共5页
New Chinese Medicine
基金
广东省基础与应用基础研究基金区域联合基金项目(22202107190000253)。
关键词
急性缺血性脑卒中
溶栓
电针
自噬因子
神经功能
生活质量
Acute ischemic stroke
Thrombolysis
Electro-acupuncture
Autophagy factors
Neuro-logicalfunction
Qualityof life
