摘要
Comprehensive Summary,C-Glycosides are critical,naturally occurring products and medicinal candidates,and extensive efforts have been made to explore efficient approaches for creating C-glycosidic bonds.Transition-metal-catalysis,particularly nickel-catalyzed C-glycosylation reactions constitute a promising strategy.However,achieving a stereoselective synthesis ofα-andβ-C-glycosides has been a long-standing challenge.To address this problem,a variety of nickel-mediated strategies have been developed.This review highlights recent developments in the nickel-catalyzed diastereoselective C-glycosylation reactions and briefly summarizes the mechanistic understandings of these methods.
基金
the National Natural Science Foundation of China(21907071,21922106,and T2221004)
Fok Ying Tung Education Foundation for financial support.
