摘要
目的探讨多巴丝肼片联合普拉克索(PPX)对帕金森病(PD)患者认知功能及血清γ-氨基丁酸(GABA)、胰岛素样生长因子1(IGF-1)水平的影响。方法抽取濮阳市安阳地区医院2020年3月至2022年5月收治的116例PD患者为研究对象,采用随机数字表法分为A组和B组,每组58例。B组采用多巴丝肼治疗,A组采用多巴丝肼联合PPX治疗。比较两组临床疗效,比较两组治疗前后帕金森综合评分量表(UPDRS)评分、蒙特利尔认知评估量表(MoCA)评分、汉密尔顿抑郁量表(HAMD)评分、血清炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)]水平、血清IGF-1、GABA、重组人帕金森病蛋白7(PARK7)、神经营养因子-3(NT-3)水平,比较两组不良反应发生率。结果A组总有效率(94.83%,55/58)高于B组(82.76%,48/58),P<0.05。治疗3个月后,A组MoCA、HAMD评分高于B组,UPDRS评分低于B组(P<0.05);治疗3个月后,A组血清IL-10水平高于B组,血清IL-1β、TNF-α、IL-6水平低于B组(P<0.05);治疗3个月后,A组血清PARK7水平低于B组,血清IGF-1、GABA、NT-3水平高于B组(P<0.05)。A组不良反应发生率(10.34%,6/58)与B组(5.17%,3/58)比较差异未见统计学意义(P>0.05)。结论PPX辅助治疗PD患者的疗效显著,可有效改善临床症状,缓解其抑郁状态,缓解炎性反应,促进病情恢复。
Objective To investigate the effects of dobutamine combined with pramipexole(PPX)on cognitive function and levels of serumγ-aminobutyric acid(GABA)and insulin-like growth factor 1(IGF-1)in patients with Parkinson disease(PD).Methods A total of 116 patients with PD admitted to Anyang District Hospital from March 2020 to May 2022 were selected as study subjects,and they were divided into group A and group B by random number table method,with 58 cases in each group.Group B was treated with dobutamine,and group A was treated with dobutamine combined with PPX.The clinical efficacy of the two groups were compared.The unified Parkinson disease rating scale(UPDRS)score,Montreal cognitive assessment scale(MoCA)score,Hamilton depression scale(HAMD)score,levels of serum inflammatory factors,including tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6)and interleukin-10(IL-10),serum IGF-1 level,GABA level,recombinant human Parkinson disease protein 7(PARK7)level,and neurotrophic factor-3(NT-3)level were compared between the two groups before and after 3 months of treatment.The incidence of adverse reactions of the two group were compared.Results The total effective rate of group A(94.83%,55/58)was higher than that of group B(82.76%,48/58),P<0.05.The scores of MoCA and HAMD of group A were higher than those of group B,and UPDRS score was lower than that of group B after 3 months of treatment(P<0.05).The serum IL-10 level of group A was higher than that of group B,and levels of serum IL-1β,TNF-αand IL-6 were lower than those in group B after 3 months of treatment(P<0.05).The serum PARK7 level in group A was lower than that in group B,and levels of serum IGF-1,GABA,NT-3 were higher than those in group B after 3 months of treatment(P<0.05).There was no significant difference in overall incidence of adverse reactions between group A(10.34%,6/58)and group B(5.17%,3/58),P>0.05.Conclusions PPX adjuvant therapy for PD patients is effective in improving clinical symptoms,relieving inflammatory response,alleviating depression condition and promoting recovery.
作者
何昕
张博爱
邓建中
郭龑
He Xin;Zhang Boai;Deng Jianzhong;Guo Yan(Department of Neurology I,Anyang District Hospital,Anyang 455000,China;Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《中国实用医刊》
2023年第18期100-103,共4页
Chinese Journal of Practical Medicine
