摘要
In recent years,more and more reports have been reported on the extracellular role of vitamin D signaling pathway.Studies have shown that both genomic and non-genomic effects of vitamin D signaling pathway are involved in calcium homeostasis,skeletal effects,cell proliferation,differentiation,oxidative stress,angiogenesis,inflammatory response,immune regulation,production and recognition of antimicrobial peptides to varying degrees.This paper reviews the research progress of key genes such as GC,CYP2R1,CYP24A1,CYP27B1,VDR and RXRαin vitamin D receptor signaling pathway,in order to understand the physiological and pathological mechanisms of this pathway more accurately and comprehensively,and lay a foundation for further research.
基金
National Natural Science Foundation of China(No.81860551)
Key Research and Development Project of Hainan Province(No.ZDYF2018156)。
