摘要
动脉粥样硬化的发病机制与内皮损伤、免疫以及细胞增殖、凋亡等密切相关。Piezo1是一种新型的机械敏感阳离子通道,能通过调控内皮细胞、免疫细胞、血管平滑肌细胞等途径干预动脉粥样硬化的发生发展。研究发现,丹参、黄芪-丹参、人参皂苷Rg1-三七皂苷R1-原儿茶醛干预动脉粥样硬化的机制与Piezo1通道密切相关。今后可基于Piezo1通道开展更多中药干预动脉粥样硬化的研究。参考文献35篇。
The pathogenesis of atherosclerosisis is closely related to endothelial injury,immunity,and prolife-ration and apoptosis of cells.Piezo1,a novel mechanosensitive cationic channel,is involved in the development of atherosclerosis in several aspects,including regulating endothelial cells,immune cells,and vascular smooth muscle cells.Researches have found that the mechanism of intervention in atherosclerosisis by Danshen(Salviae Miltiorrhizae Radix et Rhizoma),Huangqi(Astragali Radix)-Danshen,and Ginsenoside Rg1-Notoginsenoside R1-Protocatechuic aldehyde is closely related to Piezo1 channel.More researches on Chinese materia medica in intervention in atherosclerosisis based on Piezo1 channel should be conducted in future.Reference list includes 35 articles.
作者
文礼珍
夏明峰
徐涵
洪甜影
赵莹
李静
WEN Lizhen;XIA Mingfeng;XU Han;HONG Tianying;ZHAO Ying;LI Jing(Innovation Research Institute of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
出处
《山东中医杂志》
2023年第11期1240-1244,共5页
Shandong Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(编号:82174196)
山东省自然科学基金重大基础研究项目(编号:ZR2020ZD16)
山东省自然科学青年基金项目(编号:ZR2022QH340)。
