摘要
动物模型广泛应用于研究疾病的发病机制及药物干预的安全性、疗效、作用机制等研究。选择和制备符合疾病发病规律的动物模型是开展实验研究的基础和前提。糖尿病大血管病变的特征为广泛且进展迅速的血管壁动脉粥样硬化,小鼠是动脉粥样硬化实验研究中运用最广泛的动物。本文基于最新研究结果根据1型和2型糖尿病的特征、糖尿病动脉粥样硬化斑块发展规律以及相关评估技术对糖尿病动脉粥样硬化小鼠模型进行系统性综述。
Animal modelsarewidely used to study thepathogenesisof diseasesand thesafety,efficacy,and mechanisms of drug treatments.The selection and preparation of animal models that conform to the law of disease incidence are the basis and premise of experimental research.Diabetes macroangiopathy is characterized by extensive and rapidly progressing atherosclerosis of vascular walls.Mice are the most widely used experimental animals in atherosclerosis research.On the basis of the current research information and in accordance with the characteristics of type 1 and 2 diabetes,the development of diabetic atherosclerotic plaques,and the current monitoring technologies,this article systematically reviews diabetic atherosclerosis mouse models.
作者
杨燕
陈正涛
肖华胜
高泓
谢春光
YANG Yan;CHEN Zhengtao;XIAO Huasheng;GAO Hong;XIE Chunguang(Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Traditional Chinese Medicine Regulating Metabolie Diseases Key Laboratory of Sichuan Province,Chengdu 610075;Shanghai Biotechnology Coporation,Shanghai 201203)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2023年第9期1194-1205,共12页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然基金面上项目(81973585)
四川省中医药管理局重大疾病中医药、中西医结合临床循证评价研究项目(2020ZD001)
国家中医药传承创新团队项目(ZYYCXTD-C-202209)。
关键词
糖尿病大血管病变
动脉粥样硬化
小鼠模型
diabetes macroangiopathy
atherosclerosis
mouse model Conflicts of Interest:The authors declare no conflict of interest.
