摘要
温石棉是生活中广泛应用的矿物材料,其致纤维化、致癌性是公众关注较多的公共卫生问题。目前,已有50多个国家全面禁止进口和使用温石棉,但中国仍是世界上最大的温石棉消费国和第二大生产国,职业暴露人群庞大。调查显示温石棉矿工患肺纤维化、肺癌和间皮瘤的概率明显高于其他职业工作者。但温石棉诱发癌症的潜伏期一般长达数十年,难以及时发现和治疗,因此温石棉暴露所致的癌症死亡人数较多,是职业性癌症死亡的主要原因。上皮间质转化是组织、器官发生慢性炎症、纤维化、癌变及癌转移等生物学过程的关键步骤,在温石棉暴露所致肺纤维化、肺癌及其他疾病中发挥着重要作用。本文主要从炎症因子的表达水平变化、丝裂原活化蛋白激酶通路及氧化应激等其他生物学途径对温石棉诱导上皮间质转化的机制研究现状进行概述,并提出进一步研究温石棉诱导上皮间质转化可能的研究方向,为深入研究温石棉暴露对肺纤维化、肺癌等疾病的发生发展奠定基础,提供可靠的依据与参考。
As a mineral material widely used in life,chrysotile is a public health concern for its fibrogenicity and carcinogenicity.Currently,more than 50 countries have completely banned the import and use of chrysotile,but China is still the world's largest consumer and second largest producer of chrysotile,with a large occupationally exposed population.Investigations have shown that chrysotile miners are significantly more likely to develop pulmonary fibrosis,lung cancer,and mesothelioma than workers in other occupations.Chrysotile-induced cancers generally have a decades-long latency period and are difficult to diagnose and treat in a timely manner.Therefore,the cancer fatality due to chrysotile exposure is significant and is a leading contributor to occupational cancer death.Epithelial mesenchymal transition is a key step in the biological processes of chronic inflammation,fibrosis,carcinogenesis,and cancer metastasis in tissues and organs,also plays an important role in pulmonary fibrosis,lung cancer,and other diseases due to chrysotile exposure.This paper summarized the mechanisms of chrysotile inducing epithelial interstitial transition from dynamics of inflammatory factors,mitogen-activated protein kinase pathways,oxidative stress,and other biological pathways,and proposed possible research directions for further study on chrysotile-induced epithelial mesenchymal transition,aiming to provide a reliable basis and reference for in-depth research on pulmonary fibrosis,lung cancer,and other diseases due to chrysotile exposure.
作者
何佳睿
邓建军
HE Jiarui;DENG Jianjun(School of Laboratory Medicine,Chengdu Medical College,Chengdu,Sichuan 610500,China;Department of Laboratory Medicine,Sichuan Mianyang 404 Hospital,Mianyang,Sichuan 621000,China)
出处
《环境与职业医学》
CAS
CSCD
北大核心
2023年第9期1090-1094,共5页
Journal of Environmental and Occupational Medicine
基金
国家自然科学基金项目(41472046)
四川省医学科研课题计划项目(S20029)。
关键词
温石棉
上皮间质转化
作用机制
炎症因子
丝裂原活化蛋白激酶
氧化应激
chrysotile
epithelial mesenchymal transition
mechanism
inflammatory factor
mitogen-activated protein kinase
oxidative stress
