摘要
目的探讨脓毒症心肌损伤患者血清心型脂肪酸结合蛋白(h-FABP)、微小RNA-155-5P(miR-155-5P)、微小RNA-499a-5P(miR-499a-5P)表达与预后的关系。方法选取2019年1月-2021年3月在本院就诊的脓毒症患者124例,其中合并有心肌损伤患者52例(心肌损伤组),无心肌损伤患者72例(无心肌损伤组),分析比较2组血清h-FABP、miR-155-5P、miR-499a-5P以及肌酸激酶同工酶(CK-MB)、氨基末端B型脑钠肽前体(NT-proB-NP)和左室射血分数(LVEF)差异。结果心肌损伤组患者血清h-FABP、miR-155-5P、miR-499a-5P、CK-MB和NT-proBNP高于无心肌损伤组(P<0.05),而LVEF低于无心肌损伤组(P<0.05);血清h-FABP、miR-155-5P、miR-499a-5P与NT-proBNP成正相关(P<0.05),而与LVEF成负相关(P<0.05);心肌损伤组死亡患者血清h-FABP、miR-155-5P、miR-499a-5P和NT-proBNP高于存活患者(P<0.05);血清h-FABP、miR-155-5P和miR-499a-5P预测脓毒症心肌损伤患者死亡的ROC曲线下面积分别为0.817、0.775和0.706(P<0.05);血清NT-proBNP预测脓毒症心肌损伤患者死亡的ROC曲线下面积为0.644(P>0.05)。结论脓毒症心肌损伤患者血清h-FABP、miR-155-5P、miR-499a-5P表达水平升高,与NT-proBNP及LVEF有一定相关性,同时在预测脓毒症心肌损伤患者预后中有一定价值。
Objective This paper aims to investigate the relationship between prognosis and the serum expression of heart-type fatty acid-binding protein(h-FABP),minute RNA-155-5P(miR-155-5P)and minute RNA-499a-5P(miR-499a-5P)in patients with sepsis myocardial injury.MethodsA total of 124 patients with sepsis in our hospital from January 2019 to March 2021 were selected,including 52 patients with myocardial injury(myocardial injury group)and 72 patients with-out myocardial injury(no myocardial injury group),and the differences of serum h-FABP,miR-155-5P,miR-499a-5P,CK-MB,NT-proBNP and LVEF between the two groups were analyzed and compared.Results The serum levels of h-FABP,miR-155-5P,miR-499a-5P,CK-MB and NT-proBNP in myocardial injury group were significantly higher than that in the group without myocardial injury(P<0.05);LVEF was significantly lower than that in the group without myo-cardial injury(P<0.05).Serum h-FABP,miR-155-5P,miR-499a-5P were positively correlated with NT-proBNP(P<0.05),while negatively correlated with LVEF(P<0.05).The serum levels of h-FABP,miR-155-5P,miR-499a-5P and NT-proBNP in the deceased patients of myocardial injury group were higher than the survival patients(P<0.05).The areas under the ROC curve of serum h-FABP,miR-155-5P and miR-499a-5P for predicting death in patients with septic myocardial injury were 0.817,0.775 and 0.706,respectively(P<0.05),and the area under the R0C curve of serum NT-proBNP in predicting the death of patients with septic myocardial injury was 0.644(P>0.05).Conclu-sion The levels of serum h-FABP,miR-155-5P and miR-499a-5P in patients with septic myocardial injury increase,which is correlated with NT-proBNP and LVEF to a certain extent,and has a certain value in predicting the prognosis of patients with septic myocardial injury.
作者
马欣
王建峰
MA Xin;WANG Jian-feng(Department of Critical Care Medicine,the Second People's Hospital of Jiaozuo City(the First Afiliated Hospital of Henan University of Technology),Henan 473402,China)
出处
《中国卫生检验杂志》
CAS
2023年第21期2614-2617,共4页
Chinese Journal of Health Laboratory Technology
基金
焦作市二〇二二年科技计划项目(2022430011)。
