摘要
目的 探讨多发性骨髓瘤化疗后合并肺部感染患者呼吸及炎症指标水平。方法 回顾性分析2019年11月-2021年11月在本院接收化疗的80例多发性骨髓瘤患者的临床资料,根据患者是否发生肺部感染分为感染组和未感染组两组,每组各40例,其中感染组患者根据其感染严重程度将患者分为轻度感染组(11例)、中度感染组(20例)和重度感染组(9例)三组。对感染组和未感染组以及不同程度感染患者的呼吸和炎症指标水平进行比较。结果 相较于未感染组,感染组RAW、Fres、Pmean和PCT、hs-CRP、TNF-α、IL-6表达水平均明显更高(P<0.05),Cdyn明显更低(P<0.05);随着感染严重程度增加患者RAW、Fres、Pmean逐渐升高(P<0.05),PCT、hs-CRP、TNF-α、IL-6表达水平逐渐上升(P<0.05),Cdyn逐渐降低(P<0.05);多发性骨髓瘤化疗后合并肺部感染患者呼吸指标RAW、Fres、Pmean和炎症指标PCT、hs-CRP、TNF-α、IL-6表达水平与感染严重程度呈正相关(P<0.05),与Cdyn呈负相关(P<0.05)。结论 多发性骨髓瘤化疗后合并肺部感染患者呼吸和炎性指标均会发生明显变化,对患者呼吸和炎症指标进行测定对多发性骨髓瘤患者化疗后肺部感染诊断和感染严重程度判断具有重要意义。
Objective To investigate the level of respiratory and inflammatory markers in patients with multiple myeloma complicated with pulmonary infection after chemotherapy.Methods The clinical data of 80 patients suffered from multiple myeloma who received chemotherapy in our hospital from November 2019 to November 2021 were analyzed respectively,they were divided into infected group and uninfected group according to whether the patients complicated with pulmonary infection,with 40 cases in each group.The patients in the infected group were divided into three groups according to the severity of their infection:mild infection group(11 cases),moderate infection group(20 cases)and severe infection group(9 cases).The levels of respiratory and inflammatory indicators were compared between the infected group and the uninfected group,as well as patients with different degrees of infection.Results Compared with the uninfected group,the level of RAW,Fres,and Pmean,the expression level ofPCT,hs_CRP,TNF-α,and IL-6 in the infected group were significantly higher(P<0.05),however,the level of Cdyn was significantly lower(P<0.05).With the increase of infection severity,RAW,Fres,Pmean gradually increased(P<0.05);the expression level of PCT,hs-CRP,TNF-α,IL-6 gradually increased(P<0.05);while Cdyn gradually decreased(P<0.05).Respiratory indexes RAW,Fres,Pmean and the expression level ofinflammatory indexes PCT,hs_CRP,TNF-α,IL-6in patients with multiple myeloma complicated with pulmonary infection after chemotherapy were positively correlated with the severity of infection(P<0.05),and negatively correlated with Cdyn(P<0.05).Conclusions The respiratory and inflammatory indicators of patients with multiple myeloma complicated with pulmonary infection will change significantlyafter chemotherapy.The determination of respiratory and inflammatory indicators is of great significance for the diagnosis of pulmonary infection and the judgment of the severity of infection.
作者
王琼
庞迎旭
米瑞华
Wang Qiong;Pang Yingxu;Mi Ruihua(Hematology Department,Zhoukou Central Hospital,Zhoukou,Henan466000,China)
出处
《齐齐哈尔医学院学报》
2023年第17期1654-1658,共5页
Journal of Qiqihar Medical University
关键词
多发性骨髓瘤
肺部感染
化疗
呼吸指标
炎症指标
Multiple myeloma
Pulmonary infection
Chemotherapy
Respiratoryindicators
Inflammatory indicators
