摘要
目的 分析全国名中医张杰教授治疗慢性萎缩性胃炎(chronic atrophic gastritis, CAG)的用药规律,探究其处方核心药物的潜在作用机制。方法 搜集、整理张杰教授治疗CAG病案的有效处方1019首,利用Office 2016构建数据库,通过数据挖掘软件对处方用药进行频数、功效分类、关联规则、系统聚类、药物因子等统计分析,通过BATMAN-TCM对处方核心配伍药对党参-蒲公英的成分潜在靶点进行疾病富集以及KEGG生物学通路富集分析。结果 1019首CAG处方共使用中药206味,其中包含补虚药、清热药、活血化瘀药等19大类,用药频数高达19232次,频数>94次的有50味;关联规则中有药物二项关联组合30项,三项关联组合26项,从关联网络图可得党参-蒲公英-黄芪-莪术之间关系紧密;药物系统聚类分为两大类,共得到18组药物组合;药物因子分析提取出13个公因子;生物信息学分析得到党参-蒲公英药对潜在靶点关联的TTD疾病252种,KEGG通路146条,与CAG相关的信号通路9条。结论 CAG以脾胃虚弱为根本内因,瘀毒为标,张杰主任医师用药以补虚扶正为先,解毒化瘀为要,注重气血,寒温并用,以补益脾胃、解毒化瘀主治,自创萎胃散等良方,结合经方,临证加减,而核心药对的生物信息学分析可能与9条通路相关,需进一步研究。
Objective To analyze the medication patterns of Professor ZHANG Jie,a nationally renowned traditional Chinese medicine,in the treatment of chronic atrophic gastritis(CAG)and explore the potential mechanism of action of his prescription core drugs.Methods Collect and organize 1019 effective prescriptions for Professor ZHANG Jie's treatment of CAG medical records,use Office 2016 to build a database,and use data mining software to conduct statistical analysis on prescription medication frequency,efficacy classification,association rules,system clustering,drug factors,and other factors.Use BATMAN-TCM to conduct disease enrichment and KEGG biological pathway enrichment analysis on the potential targets of Codonopsis pilosula dandelion components in the core compatibility drugs of the prescription.Results The results showed that a total of 206 traditional Chinese medicines were used in 1019 CAG prescriptions,including 19 categories such as tonifying deficiency drugs,clearing heat drugs,and promoting blood circulation and resolving blood stasis drugs.The frequency of use was as high as 19232 times,with 50 prescriptions having a frequency greater than 94 times;There are 30 drug binary association combinations and 26 triple association combinations in the association rules.From the association network graph,it can be seen that there is a close relationship between Codonopsis pilosula Taraxacum Astragalus Curcuma and Curcuma zedoary;The drug system clustering is divided into two categories,with a total of 18 drug combinations obtained;Drug factor analysis extracted 13 common factors;Bioinformatics analysis revealed 252 potential target associated TTD diseases,146 KEGG pathways,and 9 CAG related signaling pathways associated with Codonopsis pilosula dandelion drugs.Conclusion CAG takes spleen and stomach weakness as the fundamental internal cause and blood stasis as the standard.Chief physician ZHANG Jie prioritizes the use of tonifying deficiency and tonifying the body,detoxifying and resolving blood stasis,emphasizing the combination of Qi and blood,cold and warm,to tonify the spleen and stomach,detoxify and remove blood stasis,and to create self created nourishing stomach powder and other effective formulas.Combined with classic formulas,clinical modifications are needed.The bioinformatics analysis of core drug pairs may be related to 9 pathways,and further research is needed.
作者
赵建根
李家劼
刘金星
郭锦晨
吴凡
张杰
李玲秀
ZHAO Jiangen;LI Jiajie;LIU Jinxing;GUO Jinchen;WU Fan;ZHANG Jie;LI Lingxiu(Anhui University of Chinese Medicine,Hefei 230012,China)
出处
《陕西中医药大学学报》
2023年第6期36-45,共10页
Journal of Shaanxi University of Chinese Medicine
基金
国家名医经验传承创新项目(OP2100000353)
国家中医药管理局全国名老中医药专家张杰传承工作室建设项目(国中医药人教发[2012]149号)
安徽省级师承培养项目(OP2000000511)
安徽省高校人文社会科学研究重点项目(SK2019A0231)
安徽中医药大学校级自然科学基金项目(2020zryb02)。
关键词
慢性萎缩性胃炎
张杰
中药
数据挖掘
用药特色
网络药理学
生物信息学
Chronic atrophic gastritis
ZHANG Jie
Traditional Chinese Medicine
Data mining
Medication characteristics
Network pharmacology
Bioinformatics
