摘要
目的 分析非小细胞肺癌患者采取微创肺叶切除术与肺段切除术治疗的效果、免疫功能及预后。方法 选择80例非小细胞肺癌患者,依据随机数字表法划分为对照组和研究组,每组40例。对照组开展微创肺叶切除术治疗,研究组开展微创肺段切除术治疗。比较两组手术指标,手术前后的免疫功能、肺功能水平及并发症发生情况。结果 研究组手术用时(150.46±13.41)min、住院时间(5.75±1.13)d均短于对照组的(160.52±14.65)min、(7.63±1.17)d,术中出血量(102.53±10.36)ml、胸腔引流量(263.75±23.59)ml均少于对照组的(152.24±16.73)、(316.82±27.54)ml,差异有统计学意义(P<0.05)。治疗后,研究组CD3+(60.84±6.93)%、CD4+(41.83±5.14)%、CD4+/CD8+(1.97±0.56)均高于对照组的(54.93±6.21)%、(37.46±5.61)%、(1.68±0.53),差异有统计学意义(P<0.05)。治疗后,研究组第1秒用力呼气容积(FEV1)占预计值百分比(84.64±4.23)%、FEV1/用力肺活量(FVC)(86.23±4.87)%、最大通气量(MVV)(82.64±6.34)L/min均高于对照组的(77.31±5.45)%、(79.12±3.56)%、(75.53±5.37)L/min,差异有统计学意义(P<0.05)。研究组并发症发生率5.00%低于对照组的20.00%,差异有统计学意义(P<0.05)。结论 相比微创肺叶切除术,非小细胞肺癌患者开展微创肺段切除术治疗的效果更佳,能促使患者免疫功能提升,减少并发症,临床上值得推广使用。
Objective To analyze the effect of minimally invasive lobectomy and segmental resection in the treatment of non-small cell lung cancer and its influence on immune function and prognosis.Methods A total of 80 patients with non-small cell lung cancer were divided into a control group and a study group according to the random numerical table,with 40 cases in each group.The control group underwent minimally invasive lobectomy,and the study group underwent minimally invasive segmental resection.The surgical indexes,the level of immune function and lung function before and after surgery and complications were compared between the two groups.Results The operative time of(150.46±13.41)min and hospital stay of(5.75±1.13)d in the study group were shorter than those of(160.52±14.65)min and(7.63±1.17)d in the control group;the intraoperative blood loss of(102.53±10.36)ml and thoracic drainage flow of(263.75±23.59)ml in the study group were lower than those of(152.24±16.73)and(316.82±27.54)ml in the control group;the differences were statistically significant(P<0.05).++After treatment,the study had CD3 of(60.84±6.93)%,CD4 of(41.83±5.14)%,CD4+/CD8+of(1.97±0.56),which were higher than those of(54.93±6.21)%,(37.46±5.61)%,(1.68±0.53)in the control group,and the differences were statistically significant(P<0.05).After treatment,in the study group,the forced expiratory volume in one second(FEV1)as a percentage of the predicted value was(84.64±4.23)%,FEV1/forced vital capacity(FVC)was(86.23±4.87)%,and the maximum ventilation volume(MVV)was(82.64±6.34)L/min,which were higher than those of(77.31±5.45)%,(79.12±3.56)%,and(75.53±5.37)L/min in the control group,and the differences were statistically significant(P<0.05).The complication rate of the study group was 5.00%,which was lower than that of 20.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with minimally invasive lobectomy,minimally invasive segmental resection for patients with non-small cell lung cancer has a better effect,which can improve the immune function of patients and reduce complications,and is worthy of clinical promotion and use.
作者
宋伟
王恩华
SONG Wei;WANG En-hua(Department of Thoracic Surgery,Zoucheng People's Hospital,Jining 273500,China)
出处
《中国现代药物应用》
2023年第21期22-25,共4页
Chinese Journal of Modern Drug Application
关键词
非小细胞肺癌
微创
肺叶切除术
肺段切除术
治疗效果
免疫功能
Non-small cell lung cancer
Minimally invasive
Lobectomy
Segmental resection
Therapeutic effect
Immune function
