摘要
目的 分析银杏叶提取物联合依达拉奉治疗急性脑梗死的疗效。方法 78例急性脑梗死患者,随机分为对照组和观察组,每组39例。对照组给予依达拉奉治疗,观察组在对照组基础上增加银杏叶提取物治疗。比较两组总住院时间,治疗前后超敏C反应蛋白、神经功能缺损程度、血液流变指标(脑血管流速、血管外周阻力、血管动态阻力、脑血管平均流量),治疗效果及不良反应发生情况。结果 观察组总住院时间(12.56±2.53)d短于对照组的(16.12±3.34)d,差异有统计学意义(P<0.05)。治疗前,两组超敏C反应蛋白、神经功能缺损程度评分、脑血管流速、血管外周阻力、血管动态阻力、脑血管平均流量比较,差异无统计学意义(P>0.05)。治疗后,观察组超敏C反应蛋白(6.53±0.32)mg/L、神经功能缺损程度评分(6.34±0.31)分均明显低于对照组的(8.52±0.26)mg/L、(12.24±0.52)分,血管外周阻力(1317.15±122.01)kPa·s/m、血管动态阻力(310.51±13.46)kPa·s/m均明显小于对照组的(1521.35±131.21)、(378.56±16.01)kPa·s/m,脑血管流速(20.12±3.45)cm/s、脑血管平均流量(14.24±2.33)ml/s均明显大于对照组的(18.50±3.23)cm/s、(12.25±2.02)ml/s,差异有统计学意义(P<0.05)。观察组总有效率97.44%(38/39)高于对照组的79.49%(31/39),差异有统计学意义(P<0.05)。两组均无明显不良反应发生。结论 急性脑梗死采用依达拉奉联合银杏叶提取物治疗效果确切。
Objective To analyze the curative effect of ginkgo biloba extract combined with edaravone in the treatment of acute cerebral infarction.Methods A total of 78 patients with acute cerebral infarction were randomly divided into a control group and an observation group,with 39 cases in each group.The control group was treated with edaravone,and the observation group was treated with ginkgo biloba extract.Both groups were compared in terms of total hospital stay,hypersensitive C-reactive protein,neurological deficit score,blood rheology indexes(cerebral blood flow velocity,peripheral vascular resistance,dynamic vascular resistance,mean cerebral blood flow),therapeutic effect and occurrence of adverse reactions.Results The total hospital stay of(12.56±2.53)d in the observation group was shorter than that of(16.12±3.34)d in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in terms of hypersensitive C-reactive protein,degree of neurological deficit,cerebral blood flow velocity,peripheral vascular resistance,vascular dynamic resistance and mean cerebral blood flow between the two groups(P>0.05).After treatment,the hypersensitive C-reactive protein of(6.53±0.32)mg/L and score of neurological deficit of(6.34±0.31)points in the observation group were significantly lower than those of(8.52±0.26)mg/L and(12.24±0.52)points in the control group;the peripheral vascular resistance of(1317.15±122.01)kPa·s/m and the dynamic vascular resistance of(310.51±13.46)kPa·s/m in the observation group were significantly lower than those of(1521.35±131.21)and(378.56±16.01)kPa·s/m in the control group;the cerebral blood flow velocity of(20.12±3.45)cm/s and mean cerebral blood flow of(14.24±2.33)ml/s in the observation group were significantly higher than those of(18.50±3.23)cm/s and(12.25±2.02)ml/s in the control group;the differences were statistically significant(P<0.05).The total effective rate of the observation group was 97.44%(38/39),which was higher than that of 79.49%(31/39)of the control group,and the difference was statistically significant(P<0.05).No obvious adverse reactions occurred in both groups.Conclusion Edaravone combined with ginkgo biloba extract is effective in the treatment of acute cerebral infarction.
作者
史继美
SHI Ji-mei(The Second Hospital of Jinzhou City,Jinzhou 121000,China)
出处
《中国现代药物应用》
2023年第21期66-68,共3页
Chinese Journal of Modern Drug Application
关键词
银杏叶提取物
依达拉奉
急性脑梗死
疗效
Ginkgo biloba extract
Edaravone
Acute cerebral infarction
Curative effect
