摘要
目的:观察温阳活血法治疗早期浆细胞性乳腺炎疗效及对免疫功能的影响。方法:选择2021年4月—2022年12月于我院治疗的80例浆细胞性乳腺炎患者,随机数字表法均分为两组。对照组40例,给予患者常规西医治疗,观察组40例,在常规西医治疗同时给予温阳活血法治疗。比较两组的临床疗效,治疗前、后评价患者各项中医证候评分,以及乳房红肿部位温度评分,通过疼痛视觉模拟评分(VAS)评价患者乳房疼痛情况,比较治疗前、后检测患者高迁移率族蛋白B1(HMGB1)、C反应蛋白(CRP)、中性粒细胞计数(NEUT)、白细胞计数(WBC)、泌乳素(PRL)、补体C4、免疫球蛋白IgM水平,记录两组患者6个月内复发率。结果:治疗后,观察组总有效率为95.00%,高于对照组的75.00%,差异有统计学意义(P<0.05);治疗后,观察组复发率为2.50%,低于对照组的20.00%,差异有统计学意义(P<0.05);治疗后,观察组各项中医证候评分、乳房疼痛评分、肤温评分明显低于对照组,差异有统计学意义(P<0.05);治疗后,观察组HMGB1、CRP、NEUT、WBC水平明显低于对照组,差异有统计学意义(P<0.05);治疗后,观察组补体C4、免疫球蛋白IgM、PRL水平明显低于对照组,差异有统计学意义(P<0.05)。结论:温阳活血法治疗早期浆细胞性乳腺炎患者,可降低患者HMGB1、CRP、NEUT、WBC水平,抑制机体炎症,调节机体免疫功能,降低PRL水平,减轻患者乳房疼痛,缓解患者病情,提升临床疗效,减少复发率。
Objective To observe the effect of warming Yang and activating blood circulation on early plasma cell mastitis and its influence on immune function.Methods 80 patients with plasma cell mastitis treated in hospital were selected and enrolled from April 2021 to December 2022.All patients were grouped according to random number table method.The control group(n=40)was treated with conventional western medicine,and the observation group(n=40)was treated with warming Yang and activating blood circulation at the same time.The clinical efficacy of the control group and the observation group was compared.Before and after treatment,the TCM syndrome scores of the patients were evaluated,the temperature of the red and swollen breast of the patients was scored,and the breast pain of the patients was evaluated by visual analogue scale(VAS).Before and after treatment,the levels of high mobility group protein B1(HMGB1),C-reactive protein(CRP),neutrophil count(NEUT),white blood cell count(WBC),prolactin(PRL),complement C4 and immunoglobulin IgM were detected,and the recurrence rate of the two groups within 6 months was recorded.Results After treatment,the total effective rate of the observation group was 95.00%,which was higher than 75.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the recurrence rate of the observation group was 2.50%lower than 20.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the TCM syndrome scores,breast pain scores and skin temperature scores of the observation group were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of HMGB1,CRP,NEUT and WBC in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of complement C4,immunoglobulin IgM and PRL in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Warming Yang and activating blood circulation in the treatment of patients with early plasma cell mastitis can reduce the levels of HMGB1,CRP,NEUT and WBC,inhibit the body's inflammation,regulate the body's immune function,reduce the PRL level,relieve the breast pain of patients,relieve the patient's condition,improve the clinical efficacy,and reduce the recurrence rate.
作者
赵赟
武海明
谷志海
闫璐璐
刘艳茹
赵甫刚
ZHAO Yun;WU Hai-ming;GU Zhi-hai(Western Medical Center of Shijiazhuang,Shijiazhuang 050300,China)
出处
《中国中西医结合外科杂志》
CAS
2023年第6期777-782,共6页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
河北中医药管理局科研计划项目(2022509)。
关键词
温阳活血法
浆细胞性乳腺炎
高迁移率族蛋白B1
炎症
泌乳素
免疫功能
Warming Yang and activating blood circulation
plasma cell mastitis
high mobility group protein B1
inflammation
prolactin
immune function
