摘要
目的探讨三酰甘油-葡萄糖指数(TyG)及单核细胞与淋巴细胞比值即血液单核细胞与淋巴细胞的比值(MLR)与银屑病冠心病共病的相关性。方法收集银屑病单病者61例,银屑病冠心病共病者64例的血常规、血脂、空腹血糖等资料,比较2组一般临床资料及MLR、TyG等指标。用Spearman相关性分析探讨银屑病冠心病共病与临床特征及MLR、TyG等指标的关系。Logistic回归分析探讨银屑病冠心病共病的相关危险因素,用受试者工作特征(ROC)曲线探讨不同变量对银屑病冠心病共病的诊断效能。结果银屑病冠心病共病组MLR、TyG均高于银屑病组(P<0.05)。Spearman相关性分析显示银屑病冠心病共病与MLR、TyG呈正向相关关系(P<0.05),Logistic回归分析显示性别(男性)、年龄、高血压病、MLR、TYG均为银屑病冠心病共病的显著危险因素。ROC曲线显示TYG为0.90时诊断银屑病冠心病共病效能最高,此时的敏感度为78.1%,特异度为50.8%。MLR为0.18时诊断银屑病冠心病共病效能最高,此时的敏感度为100%,特异度为27.87%。结论银屑病冠心病共病组MLR、TYG较银屑病单病组明显升高,两者均为银屑病冠心病共病的危险因素,均有较好的诊断效能。
Objective To identify the correlation of the triglyceride glucose(TyG)index and monocyte-to-lymphocyte ratio(MLR)with the comorbidities of psoriasis and coronary heart disease(CHD).Methods Clinical data of the blood routine,blood lipids and fasting blood glucose in 61 patients with psoriasis and 64 patients with the comorbidities of psoriasis and CHD were collected.Their clinical data,TyG index and MLR were compared between groups.Spearman correlation analysis was used to identify the correlation of theclinical features,TyG index and MLR with the comorbidities of psoriasis and CHD.Logistic regression models were used to evaluate the risk factors for the comorbidities of psoriasis and CHD.Receiver operating characteristic(ROC)curve was performed to assess the diagnosis efficacy of the above variables on the comorbidities of psoriasis and CHD.Results MLR and TyG index were significantly higher in patients with the comorbidities of psoriasis and CHD than those with psoriasis alone(P<0.05).Spearman correlation analysis indicated that the comorbidities of psoriasis and CHD were positively correlated with MLR and TyG index(P<0.05).Logistic regression analysis showed that sex(male),age,hypertension,MLR and TyG index were independent risk factors for the comorbidities of psoriasis and CHD.ROC curves suggested that the optimal cut-off value of TyG index for predicting the comorbidities of psoriasis and CHD was 0.90,with the sensitivity and specificity of 78.1%and 50.8%,respectively.The optimal cut-off value of MLR for predicting the comorbidities of psoriasis and CHD was 0.18,with the sensitivity of 100%and specificity of 27.87%,respectively.Conclusion MLR and TyG index are significantly enhanced in patients with the comorbidities of psoriasis and CHD than those with psoriasis alone.Both of them are risk factors for the comorbidities of psoriasis and CHD,presenting an acceptable diagnostic potential.
作者
张丽华
李艳玲
张晓光
周亚青
张远
魏凤
王凌
韩文瑞
荣蓉
郭兵申
ZHANG Lihua;LI Yanling;ZHANG Xiaoguang(The Second Hospital of Hebei Medical University,Hebei,Shijiazhuang 050000,China)
出处
《河北医药》
CAS
2023年第23期3598-3601,共4页
Hebei Medical Journal
基金
河北省卫生和计划生育委员会科研基金项目(编号:20211200)
河北省皮肤病与性病临床医学研究中心创新能力提升(编号:2057711D)
河北医科大学第二医院院级课题(编号:2HC202217)。
