摘要
目的探讨醒脑静联合氟马西尼治疗急性苯二氮䓬类(BZD)药物中毒的临床疗效。方法选取医院2019年7月至2021年7月收治的急性BZD药物中毒患者80例,随机分为观察组和对照组,各40例。对照组患者给予氟马西尼注射液,在对照组基础上,观察组患者加用醒脑静注射液。结果观察组患者的总有效率为95.00%,显著高于对照组的70.00%(P<0.05)。观察组患者的舒张压、收缩压、心率均显著低于对照组;药物平均有效时间和临床症状消失时间均明显优于对照组(P<0.05)。观察组患者的不良反应发生率为2.50%,显著低于对照组的20.00%(P<0.05)。结论醒脑静联合氟马西尼治疗急性BZD药物中毒临床疗效较好,可改善患者的生理应激反应,缩短药物平均有效时间和临床症状消失时间,且安全性较好。
Objective To investigate the clinical efficacy of Xingnaojing combined with flumazenil in the treatment of acute benzodiazepine(BZD)poisoning.Methods A total of 80 patients with acute BZD poisoning admitted to the hospital from July 2019 to July 2021 were selected and randomly divided into the observation group and the control group,with 40 cases in each group.The patients in the control group were given Flumazenil Injection,and on this basis,the patients in the observation group were given Xingnaojing Injection.Results The total effective rate in the observation group was 95.00%,which was significantly higher than 70.00%in the control group(P<0.05).The diastolic blood pressure,systolic blood pressure and heart rate in the observation group were significantly lower than those in the control group;the average effective time of the drug and the disappearance time of clinical symptoms in the observation group were significantly better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 2.50%,which was significantly lower than 20.00%in the control group(P<0.05).Conclusion Xingnaojing combined with flumazenil is clinically effective in the treatment of acute BZD poisoning,which can improve the physiological stress response,shorten the average effective time of the drug and the disappearance time of clinical symptoms of the patients,and has good safety.
作者
葛振忠
张云
张晶
钱立
GE Zhenzhong;ZHANG Yun;ZHANG Jing;QIAN Li(The Eighth People's Hospital of Wuxi,Wuxi,Jiangsu,China 214000;Wuxi People's Hospital,Nanjing Medical University,Wuxi,Jiangsu,China 214000)
出处
《中国药业》
CAS
2023年第S01期25-27,共3页
China Pharmaceuticals
