摘要
目的分析永城地区82例妊娠期甲状腺功能减退症的流行病学调查研究,以期为临床早期制定干预方案提供依据。方法以我院2019年1月至2022年12月收治256例妊娠期妇女为研究对象,根据妊娠期间是否发生甲状腺功能减退症将妊娠期妇女分为发生组(82例)和未发生组(174例)。分析妊娠期甲状腺功能减退症的流行病学特征,收集两组临床资料,比较两组年龄、孕前体重指数(BMI)、孕周、孕次、文化程度、自然流产史、孕期补充叶酸、糖尿病、妊娠期高血压、吸烟或暴露于吸烟环境、甲状腺疾病史、甲状腺过氧化物酶抗体(TPO-Ab)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血清胃饥饿素(Ghrelin)、肥胖抑制素(Obestatin)、25羟基维生素D3[25-(OH)D3]水平。Logistic多因素回归模型分析影响发生妊娠期甲状腺功能减退症的因素。结果发生组糖尿病、妊娠期高血压、甲状腺疾病史、TPO-Ab、血清Ghrelin、Obestatin、25-(OH)D3水平与未发生组相比存在显著差异(P<0.05);Logistic回归分析显示,糖尿病、妊娠期高血压、甲状腺疾病史、TPO-Ab阳性、血清Obestatin(>44.99 ng/L)是妊娠期妇女发生甲状腺功能减退症的危险因素,血清Ghrelin(>2045.88 pg/mL)、25-(OH)D3(>46.32 IU/mL)是妊娠期妇女发生甲状腺功能减退症的保护因素(P<0.05)。结论糖尿病、妊娠期高血压、甲状腺疾病史、TPO-Ab阳性、血清Obestatin、Ghrelin、25-(OH)D3均与妊娠期妇女发生甲状腺功能减退症密切相关,为临床早期针对性制定干预措施提供参考,以降低甲状腺功能减退症发生风险。
Objective To analyze the epidemiological investigation of 82 cases of hypothyroidism during pregnancy(hypothyroidism)in XX area,so as to provide evidence for early clinical intervention.Methods A total of 256 pregnant women admitted to our hospital from January 2019 to December 2022 were studied,and the pregnant women were divided into an occurrence group(82 cases)and a non-occurrence group(174 cases)according to whether hypothyroidism occurred during pregnancy.The epidemiological characteristics of hypothyroidism during pregnancy were analyzed and clinical data of the two groups were collected.Age,pre-pregnancy body mass index(BMI),gestational age,gestational age,educational level,history of spontaneous abortion,folic acid supplementation during pregnancy,diabetes mellitus,gestational hypertension,smoking or exposure to smoking,history of thyroid disease,thyroid peroxidase antibody(TPO-Ab),triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(H DL-C),low density lipoprotein cholesterol(LDL-C),serum Ghrelin,Obestatin,25 hydroxyvitamin D3[25-(OH)D3]levels.Logistic multivariate regression model was used to analyze the factors affecting the occurrence of hypothyroidism during pregnancy.Results The levels of diabetes mellitus,gestational hypertension,thyroid disease history,TPO-Ab,serum Ghrelin,Obestatin and 25-(OH)D3 in the developing group were significantly different from those in the non-developing group(P<0.05).Logistic regression analysis showed that diabetes mellitus,gestational hypertension,thyroid disease history,TPO-Ab positive and serum Obestatin(>44.99 ng/L)were risk factors for hypothyroidism in pregnant women.Serum Ghrelin(>2045.88pg/mL)and 25-(OH)D3(>46.32 IU/mL)were protective factors for hypothyroidism in pregnant women(P<0.05).Conclusion Diabetes mellitus,gestational hypertension,thyroid disease history,TPO-Ab positive,serum Obestatin,Ghrelin and 25-(OH)D3 are all closely related to hypothyroidism in pregnant women,which provides reference for formulating targeted intervention measures in early clinical stage to reduce the risk of hypothyroidism.
作者
刘天保
陈红
谢洋洋
Liu Tian-bao(Department of Medical Laboratory,Yongmei Group General Hospital,Yongcheng 476600,China)
出处
《牡丹江医学院学报》
2023年第5期96-99,共4页
Journal of Mudanjiang Medical University
