摘要
目的 探讨糖尿病肾病沙格列汀联合肾衰宁颗粒治疗对患者血糖及肾功能影响。方法 选取2020-02-10-2022-02-10枣庄市峄城区人民医院内分泌科收治的100例糖尿病肾病患者为研究对象,依据用药方法分为沙格列汀联合肾衰宁颗粒治疗组(联合用药组)、沙格列汀单独治疗组(单独用药组),各50例。分析比较2组体质量指数、血糖(包括糖化血红蛋白、空腹血糖、餐后2 h血糖)、肾功能[包括血β2-微球蛋白(β2-MG)、尿β2-MG、24 h尿蛋白、尿微量白蛋白(U-mAlb)、尿白蛋白排泄率(UAER)、尿素氮(BUN)、血肌酐(Scr)、血清白蛋白(TP)]、临床疗效、炎症指标[包括血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、氧化应激指标[包括丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)]、贫血状况[包括血红蛋白(Hb)、红细胞压积(Hct)、铁离子(Fe2+)]、生活质量、不良反应、治疗满意度。结果 联合用药组患者体质量指数、空腹血糖、餐后2 h血糖、糖化血红蛋白、血β2-MG、尿β2-MG、24 h尿蛋白、U-mAlb、UAER、BUN、Scr水平低于单独用药组,均P<0.05;TP水平高于单独用药组,P<0.05;总有效率为88.00%,高于单独用药组的66.00%,χ^(2)=6.832,P=0.009;血清IL-1β、IL-6、TNF-α、MDA水平低于单独用药组,均P<0.05;血清GSH-Px、SOD水平高于单独用药组,均P<0.05。联合用药组患者Hb、Hct、Fe2+水平及生活质量评分高于单独用药组,均P<0.05。联合用药组、单独用药组不良反应发生率分别为12.00%(6/50)和6.00%(3/50),差异无统计学意义,χ^(2)=0.488,P=0.485。联合用药组治疗满意度为92.00%(46/50),高于单独用药组的64.00%(32/50),χ^(2)=11.422,P=0.001。结论 糖尿病肾病沙格列汀联合肾衰宁颗粒治疗较沙格列汀单独治疗对患者血糖及肾功能的改善更为明显、效果更为显著。
Objective To investigate the effect of Shagliptin combined with Shenshuanning granule on blood glucose and re-nal function in patients with diabetes nephropathy.Methods A total of 1oo patients with diabetes nephropathy admitted to the Department of Endocrinology,Yicheng District People's Hospital,Zaozhuang City from February 10,2020 to Feb-ruary 10,2022 were selected as the study subjects.According to the medication method,they were divided into two groups:Shagliptin combined with Shenshuanning granules(combined medication group)and Shagliptin alone(mono-med-ication group),with 50 patients in each group.We analyzed and compared the body mass index,blood glucose(including glycated hemoglobin,fasting blood glucose,and 2-hour postprandial blood glucose),and renal function[including β2-Mi-croglobulin(β2-MG),urine β2-MG,24-hour urine protein,urinary microalbumin(U-mAlb),urinary albumin excretion rate(UAER),urea nitrogen(BUN),serum creatinine(Scr),and serum albumin(TP)] between two groups,clinical ef-ficacy,inflammatory markers[including serum interleukin-1β(IL-1p),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),oxidative stress indicators[including malondialdehyde(MDA),glutathione peroxidase(GSH-Px),superox-ide dismutase(SOD),anemia status[including hemoglobin(Hb),hematocrit(Hct),iron ion(Fe2+),quality of life,adverse reactions,and treatment satisfaction.Results In the combined medication group,the patient's body mass index,fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,and blood β2-MG,urine β2-MG,24-hour urine protein,U-mAlb,UAER,BUN,and Scr were lower than those in the monotherapy group,all P<0.05;The TP level was higher than that of the monotherapy group,P<0.05;The total effective rate was 88.00%,which was higher than the 66.00%in the single medication group(x^(2)=6.832,P=0.009);The levels of serum IL-1β,IL-6,TNF-α,MDA level were lower than those of the monotherapy group,with all P<O.05;The serum levels of GSH-Px and SOD were higher than those in the monotherapy group,both P<0.05.The Hb,Hct,Fe2+levels,and quality of life scores of patients in the combination medication group were higher than those in the single medication group,all P<0.05.The incidence of adverse reactions in the combination therapy group and the single therapy group was 12.00%(6/50)and 6.00%(3/50),respectively,with no statistically significant difference(x^(2)=0.488,P=0.485).The satisfaction rate of the combination therapy group was 92.00%(46/50),which was higher than the 64.00%(32/50)of the single therapy group,with x^(2)=11.422 and P=0.001.Conclusion Compared with Shagliptin alone,Shagliptin combined with Shenshuanning granules can improve blood glucose and renal function in patients with diabetes nephropathy more significantly.
作者
李欣
庄具东
LI Xin;ZHUANG Judong(Department of Endocrine,Yicheng District People's Hospital of Zaozhuang City,Zaozhuang 277300,China)
出处
《社区医学杂志》
CAS
2023年第18期945-949,共5页
Journal Of Community Medicine
关键词
糖尿病肾病
沙格列汀
肾衰宁颗粒
血糖
肾功能
不良反应
diabetes nephropathy
Shagliptin
Shenshuanning granules
blood sugar
renal function
adverse reactions
