摘要
目的检测分析老年慢性阻塞性肺疾病(COPD)合并肺部感染患者的病原菌特征及实验室指标。方法选取2021年1月至2022年12月在江西省于都县第二人民医院进行治疗的老年COPD合并肺部感染患者72例作为感染组,选取同期住院但未发生肺部感染的72例患者作为对照组,检测分析患者的病原菌特征及实验室指标情况。结果72例痰标本中革兰阴性菌占85%(其中占比最大的为鲍曼不动杆菌),革兰阳性菌占15%(其中占比最大的为金黄色葡萄球菌);药敏结果显示,鲍曼不动杆菌对碳青霉烯类药物耐药率为18%(7/40)。与对照组相比较,感染组患者外周血白细胞(WBC)、中性粒细胞百分比(NEUT%)、C反应蛋白(CRP)及降钙素原(PCT)水平较高,差异有统计学意义(P<0.05);与对照组相比较,感染组血清中白细胞介素(IL)-2水平较低,差异有统计学意义(P<0.05);与对照组相比较,感染组IL-6、干扰素(IFN)-γ、肿瘤坏死因子(TNF)-α水平较高,差异有统计学意义(P<0.05)。结论革兰阴性菌是导致COPD患者肺部感染的主要致病菌,在临床上需要及时检测患者实验室相关指标指导临床诊疗工作。
Objective To detect and analyze pathogens bacteria characteristics and laboratory indexes in elderly patients with chronic obstructive pulmonary disease(COPD)combined with pulmonary infection.Methods A total of 72 elderly patients with COPD combined with pulmonary infection and 72 patients without pulmonary infection in the hospital were enrolled as infection group and control group from January 2021 and December 2022,respectively.The characteristics of pathogens bacteria and laboratory indexes of the patients were detected and analyzed.Results In the 72 sputum samples,proportions of Gram-negative bacteria(mainly on Acinetobacter baumannii)and Gram-positive bacteria(mainly on Staphylococcus aureus)were 85%and 15%,respectively.The results of drug sensitivity test showed that resistance rate of Acinetobacter baumannii to carbapenems was 18%(7/40).Compared with control group,patients in the infected group had higher levels of white blood cells(WBC),neutrophil percentage(NEUT%),C-reactive protein(CRP)and procalcitonin(PCT),and the differences were statistically significant(P<0.05).Compared with control group,the level of serum IL-2 was lower in the infection group,and the differences were statistically significant(P<0.05).Compared with the control group,levels of IL-6,IFN-γand TNF-αwere higher in the infection group,and the differences were statistically significant(P<0.05).Conclusion Gram-negative bacteria are the main pathogens of pulmonary infection in with COPD,and timely testing of patients′laboratory indicators is needed to guide clinical diagnosis and treatment.
作者
谢兰英
吴春秀
Xie Lanying;Wu Chunxiu(Department of Laboratory,Yudu County Second People′s Hospital,Ganzhou,Jiangxi 342300,China)
出处
《实用医技杂志》
2023年第8期593-596,共4页
Journal of Practical Medical Techniques
关键词
肺疾病
慢性阻塞性
肺部感染
病原菌
实验室指标
Pulmonary disease
Chronic obstructive
Pulmonary infection
Pathogen
Laboratory index
