摘要
炎症性肠病(inflammatory bowel disease,IBD)主要表现为慢性进行性胃肠道炎症,损害胃肠道黏膜。越来越多的研究证明,炎症部位存在失调的细胞死亡,导致肠道机械屏障的破坏和炎症反应的加重。铁死亡是一种新发现的铁依赖的、脂质氧化介导的细胞死亡形式。已有多篇文献报道了IBD患者的肠道出现铁死亡相关因子的异常,鉴于当前IBD具体发病机制尚不明确,且治疗尚存在诸多局限,因此,该文总结了近年来铁死亡机制的研究进展,并重点阐述了铁死亡在IBD发病机制中的潜在作用,为未来IBD发病机制的研究与治疗药物的开发运用提供方向。
Inflammatory bowel disease(IBD)is a chronic progressive inflammation of the gastrointestinal tract that damages the mucous membrane of the gastrointestinal tract.A growing number of studies have demonstrated that dysfunctional cell death occurs at inflammatory sites,leading to the destruction of the intestinal mechanical barrier and aggravation of inflammatory responses.Ferroptosis is a newly discovered form of programmed cell death mediated by iron-dependent lipid oxidation.There have been many articles that reported intestinal abnormal related factors of ferroptosis in patients with IBD.In view of the unclear current IBD specific pathogenesis and the many limitations in treatment,we summarize the research progress of ferroptosis mechanism in recent years,and expound the potential role of ferroptosis in the pathogenesis of IBD,aiming to provide direction for the future study of the pathogenesis of IBD and the development and application of therapeutic drugs.
作者
陈双兰
刘青松
胡双元
张怡
刘蓉
CHEN Shuang-lan;LIU Qing-song;HU Shuang-yuan;ZHANG Yi;LIU Rong(Dept of Gastroenterology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2023年第12期2210-2215,共6页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81973821)。
关键词
铁死亡
炎症性肠病
肠上皮细胞
氧化应激
机制
研究进展
ferroptosis
inflammatory bowel disease
intestinal epithelial cells
oxidative stress
mechanism
research progress
