摘要
目的探讨血清苄氯素1(BECN1)、沉默信息调节因子6(SIRT6)水平与ST段抬高型心肌梗死(STEMI)患者经皮冠脉介入治疗(PCI)术后缺血再灌注损伤(IRI)的关系。方法选取150例STEMI患者为STEMI组,根据PCI术后是否发生IRI分为IRI组和非IRI组,另选取同期68例健康体检志愿者为对照组。采用酶联免疫吸附法检测血清BECN1、SIRT6水平。分析STEMI患者术后IRI的影响因素,绘制血清BECN1、SIRT6水平诊断STEMI患者术后发生ISI的受试者工作特征(ROC)曲线。结果与对照组比较,STEMI组血清BECN1、SIRT6水平降低(P均<0.05)。150例STEMI患者PCI术后IRI发生率为38.00%(57/150)。多因素Logistic回归分析显示,年龄增加(OR=1.094,95%CI:1.019~1.174)与白蛋白(OR=0.826,95%CI:0.723~0.943)、BECN1(OR=0.880,95%CI:0.830~0.933)和SIRT6(OR=0.338,95%CI:0.204~0.558)升高为STEMI患者术后IRI的独立危险因素(P均<0.05)。ROC曲线分析结果显示,血清BECN1、SIRT6水平联合[曲线下面积(AUC)=0.872,95%CI:0.808~0.921]预测STEMI患者术后IRI的AUC大于BECN1(AUC=0.782,95%CI:0.707~0.845)、SIRT6(AUC=0.783,95%CI:0.708~0.846)单独预测(P均<0.05)。结论STEMI患者血清BECN1、SIRT6水平降低与术后IRI密切相关,血清BECN1、SIRT6水平联合预测STEMI患者术后IRI的价值较高,可作为STEMI患者术后IRI的辅助预测指标。
Objective To investigate the relationships between serum Beclin1(BECN1)and silent information regu⁃lator transcript 6(SIRT6)levels and postoperative ischemia-reperfusion injury(IRI)in patients with ST-segment elevation myocardial infarction(STEMI).Methods Totally 150 STEMI patients were selected as the STEMI group,and then were divided into the IRI and non-IRI groups according to whether IRI occurred after percutaneous coronary intervention(PCI),and meanwhile,68 healthy volunteers with physical examination were selected as the control group during the same period.Serum BECN1 and SIRT6 levels were measured by enzyme-linked immunosorbent assay.We analyzed the factors influencing postoperative IRI in STEMI patients,and receiver operating characteristic(ROC)curves of serum BECN1 and SIRT6 levels were drawn.Results Compared with the control group,the serum BECN1 and SIRT6 levels were reduced in the STEMI group(both P<0.05).The incidence of IRI after PCI in 150 STEMI patients was 38.00%(57/150).Multifactorial Logistic regression analysis showed that increasing age(OR=1.094,95%CI:1.019 to 1.174)and increased albumin(OR=0.826,95%CI:0.723 to 0.943)and BECN1(OR=0.880,95%CI:0.830 to 0.933)and SIRT6(OR=0.338,95%CI:0.204 to 0.558)were independent risk and protective factors for postoperative IRI in STE⁃MI patients(all P<0.05).ROC curve analysis showed that the area under the curve(AUC)of the combined serum BECN1 and SIRT6 levels(AUC=0.872,95%CI:0.808 to 0.921)in predicting postoperative IRI in STEMI patients was greater than that of BECN1(AUC=0.782,95%CI:0.707 to 0.845)or SIRT6(AUC=0.783,95%CI:0.708 to 0.846)alone(both P<0.05).Conclusions Decreased serum BECN1 and SIRT6 levels in STEMI patients are closely related to postoperative IRI,which have a certain predictive value for postoperative IRI in STEMI patients.Serum BECN1 and SIRT6 levels are of high value in predicting postoperative IRI in STEMI patients,and may become auxiliary predictors of postoperative IRI in STEMI patients.
作者
陈作强
李洲剑
衣帕尔古力·阿布拉
巩丽华
张慧敏
CHEN Zuoqiang;LI Zhoujian;Yiparguli Abra;GONG Lihua;ZHANG Huimin(Department of Cardiovascular Medicine,Bazhou People's Hospital,Korla 841000,China;不详)
出处
《山东医药》
CAS
2023年第34期6-10,共5页
Shandong Medical Journal
基金
中国管理科学研究院教育科学研究科教创新研究重点课题(KJCX9041)
巴音郭楞蒙古自治州人民医院院级科研项目(BY202304)。
关键词
ST段抬高型心肌梗死
苄氯素1
沉默信息调节因子6
经皮冠状动脉介入治疗
缺血再灌注损伤
ST-segment elevation myocardial infarction
Beclin1
silent information regulator transcript 6
percutaneous coronary intervention
ischemia-reperfusion injury
