摘要
目的探讨脉络膜血管指数(CVI)联合血清补体1q/肿瘤坏死因子相关蛋白9(CTRP9)水平对糖尿病黄斑水肿(DME)发病风险的预测价值。方法选取156例(156眼)并发DR的2型糖尿病(T2DM)患者为DR组,根据是否发生DME分为DME组69例(眼)和非DME组87例(眼),另选取同期87例未合并DR的T2DM患者为非DR组。通过频域光相干断层扫描增强深度成像技术计算CVI,酶联免疫吸附法检测血清CTRP9。采用多因素Logistic回归分析DR患者DME发病风险的影响因素,绘制受试者工作特征(ROC)曲线分析CVI联合血清CTRP9水平对DME发病风险的预测价值。结果与非DR组相比,DR组CVI和血清CTRP9水平降低(P均<0.05)。与非DME组比较,DME组CVI和血清CTRP9水平降低(P均<0.05)。多因素Logistic回归分析显示,年龄增加、增生型DR和糖化血红蛋白升高为DR患者DME发病风险的独立危险因素,CVI和CTRP9升高为独立保护因素(P均<0.05)。ROC曲线分析显示,CVI和血清CTRP9水平单独与联合预测DME发病风险的曲线下面积分别为0.797、0.786、0.893,CVI联合血清CTRP9水平预测的曲线下面积大于二者单独预测(P均<0.05)。结论CVI和血清CTRP9水平降低与DME发病风险独立相关,CVI联合血清CTRP9水平对预测DME发病有较高价值。
Objective To investigate the predictive value of choroidal vascularity index(CVI)combined with serum complement 1q/tumor necrosis factor-related protein 9(CTRP9)level for the risk of diabetic macular edema(DME).Methods Totally 156 patients(156 eyes)with type 2 diabetes mellitus(T2DM)complicated with DR were selected as the DR group,and were divided into the DME group of 69 cases(eyes)and non-DME group of 87 cases(eyes)according to whether DME occurred or not,and 87 T2DM patients without DR in the same period were selected as the non-DR group.CVI was calculated using enhanced depth imaging optical coherence tomography,and serum CTRP9 levels were measured by enzyme-linked immunosorbent assay.Multifactorial Logistic regression was used to analyze the factors influencing the risk of DME in DR patients,and the predictive value of CVI combined with serum CTRP9 level for the risk of DME was an⁃alyzed by receiver operating characteristic(ROC)curve.Results Compared with the non-DR group,CVI and serum CTRP9 levels decreased in the DR group(both P<0.05).CVI and serum CTRP9 levels were lower in the DME group in comparison with those of the non-DME group(both P<0.05).Multifactorial Logistic regression analysis showed that in⁃creasing age,proliferative DR and elevated glycated hemoglobin were independent risk factors for the risk of DME in DR patients,and elevated CVI and CTRP9 were independent protective factors(all P<0.05).ROC curve analysis showed that the area under the curve of CVI and serum CTRP9 levels alone and in combination in predicting the risk of DME was 0.797,0.786,and 0.893,and the area under the curve of CVI combined with serum CTRP9 levels was the largest(all P<0.05).Conclusions Reduced CVI and serum CTRP9 levels were independently associated with the risk of DME,and CVI combined with serum CTRP9 levels had a high predictive value for the development of DME.
作者
杨来庆
罗广娥
张沧霞
王庆金
刘文
葛含笑
马元松
YANG Laiqing;LUO Guang'e;ZHANG Cangxia;WANG Qingjin;LIU Wen;GE Hanxiao;MA Yuansong(Department of Ophthalmology,Cangzhou Integrated Traditional Chinese and Western Medicine Hospital,Cangzhou 061000,China)
出处
《山东医药》
CAS
2023年第34期26-30,共5页
Shandong Medical Journal
基金
河北省中医药管理局中医药类科研资助项目(2023266)
河北省中医药管理局中医药类科研资助项目(2017146)。
