摘要
目的:探讨皮肤汗腺瘤的临床、组织病理及免疫组化特征。方法:对8例皮肤汗腺瘤的临床、组织病理及免疫组化结果进行回顾性分析。结果:8例患者中,男5例,女3例,平均年龄51.4岁(25~66岁)。发病部位:头部及四肢各3例,躯干2例。临床表现为皮下孤立、生长缓慢的囊性和(或)实性结节,7例境界清楚,1例界限不清。组织病理检查显示该肿瘤主要由多边形鳞状细胞样细胞和透明细胞组成,8例均可见导管分化,4例透明细胞变性,2例鳞状分化,1例见顶浆分泌现象。免疫组化显示肿瘤细胞主要表达细胞角蛋白(CK)、CK5/6、p63和P40;汗腺导管上皮膜抗原(EMA)、癌胚抗原(CEA)阳性。结论:皮肤汗腺瘤是一种少见皮肤附属器良性肿瘤;组织病理表现多样。
Objective:To investigate the clinical,histopathological and immunohistochemical features of hidradenoma.Methods:A retrospective study was performed on 8 patients diagnosed as hidradenoma from 2013 to 2021.Results:The 8 cases included 5 males and 3 females with an average age of 51.4 years(rang from 25 to 66 years).Head,extremities and trunk location were noted in 3,3 and 2 cases,respectively.The tumor presented a solitary,slow-growing,and solid or cystic nodular lesion within dermis.7 cases were well-demarcated and 1 case was pooly defined.Histological examination showed that the tumor was composed of squamoid polygonal cells and clear cells,accompanied by luminal formation in 8 cases,prominent clear cell changes in 4 cases,squamous differentiation in 2 cases and apocrine-like decapitated secretion in one case.Immunohistochemical staining revealed that the tumor cells were postive for CK,CK5/6,p40,and p63.Luminal differentiation was highlighted by epithelial membrane antigen and carcinoembryonic antigen staining.C onclusions:Hidradenoma is a rare benign tumor of skin appendages.Hidradenoma presents various histopathological manifestations.
作者
郑娇
李长新
孟思宏
李沁娜
王功伟
ZHENG Jiao;LI Changxin;Meng Sihong;Li Qinna;WANG Gongwei(Department of pathology,Shunyi Hospita,Beijing Traditional Chinese Medicine Hospital,Beijing 101300,China;Department of pathology,The People's Hospital of Peking University,Bejing 100044,China)
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2023年第12期743-746,共4页
Journal of Clinical Dermatology
关键词
汗腺瘤
临床病理
免疫组织化学
Hidradenoma
Clinicopathological
immunohistochemistry
